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Hemodynamic changes following wingspan stent placement-a quantitative magnetic resonance angiography study.
MedLine Citation:
PMID:  19732297     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Quantitative magnetic resonance angiography (QMRA) is a noninvasive imaging modality that provides anatomic and physiologic measurements of arteries. We used QMRA to assess hemodynamic changes following Wingspan stent placement for intracranial stenosis.
METHODS: We reviewed patients treated with Wingspan stents for intracranial stenosis who had baseline and follow-up QMRA data. We compared volumetric flow rates (VFRs) (mL/minute) pre- and poststenting using paired t-tests. P < .05 was considered significant.
RESULTS: Among 9 patients (mean age 65.8 years, mean 71% degree of stenosis), lesions were located in the supraclinoid internal carotid arteries in 3, middle cerebral arteries in 3, and intracranial vertebrobasilar arteries in 3. VFR and degree of stenosis were moderately correlated (r=- .670, P= .002). The mean VFR in the stenotic artery increased from 81.2 mL/minute to 133.3 mL/minute (P= .020) or by 64.2% after stenting. Total cerebral blood flow, flow in nonstented vessels, and collateral flow in circle of Willis vessels did not significantly change.
CONCLUSION: We found that QMRA is a promising noninvasive method for the measurement of cerebral hemodynamics following intracranial Wingspan stent placement. Larger prospective studies are needed to confirm our findings.
Shyam Prabhakaran; Kalani R Wells; Miral D Jhaveri; Demetrius K Lopes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  21     ISSN:  1552-6569     ISO Abbreviation:  J Neuroimaging     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e109-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 by the American Society of Neuroimaging.
From the Department of Neurological Sciences (SP); Radiology (KRW, MDJ); and Neurosurgery (DKL), Rush University Medical Center, Chicago, IL.
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