Document Detail

Hemodilution causes decreased compliance in puppies.
MedLine Citation:
PMID:  14740695     Owner:  NLM     Status:  MEDLINE    
Cardiopulmonary bypass and hemodilution in the newborn have been associated with increased myocardial edema, which may be due to immature connective tissue formation. Five adult and four puppy dogs were placed on bypass while compliance and ventricular function (intraventricular balloon) were measured during normohemoconcentration (NH) (hematocrit 45.1, osmolality 307) and hemodilution with normal saline (hematocrit 24.7, osmolality 307). Compared with NH, the adult group showed no change in compliance or function after 90 min of hemodilution. The puppy group showed a marked decrease in compliance with hemodilution compared to NH (P < 0.001) without change in ventricular function when peak systolic pressure was plotted against end-diastolic volume. Electron micrographs confirmed greater edema formation in the puppy group than the adult group with hemodilution. These changes demonstrate that the newborn heart is more sensitive to edema formation than the adult during hemodilution and that filling pressures do not necessarily reflect ventricular performance during the early post-perfusion period when compliance is decreased.
C Mavroudis; P A Ebert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  58     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1978 Sep 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-02-11     Revised Date:  2004-02-12    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  I155-9     Citation Subset:  AIM; IM    
Department of Surgery, University of California, San Francisco, San Francisco, California, USA.
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MeSH Terms
Cardiopulmonary Bypass / methods
Connective Tissue / blood supply,  growth & development
Diastole / physiology
Heart / growth & development
Heart Ventricles / ultrastructure
Hemodilution / methods*
Models, Animal
Papillary Muscles / ultrastructure*
Ventricular Function, Left / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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