| Hemodialyzability of acetazolamide. | |
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MedLine Citation:
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PMID: 7367929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because the dialyzability of acetazolamide is not known, we undertook a study to determine the in vivo dialysance of this drug and found it to average 22 ml per minute. The quantity of the drug removed by four hours of dialysis was approximately 30% of the dose administered intravenously one half hour before dialysis. Accordingly, considerable amounts of the drug are removed by dialysis, despite its high intraerythrocytic distribution and plasma protein binding properties. Therefore, hemodialysis may be effective in the management of acetazolamide overdose, particularly when complicated by the presence of renal failure. The dialysance can vary under different dialyzing conditions. An acetazolamide/urea nitrogen extraction ratio of 0.16 established in this study can be used to predict the acetazolamide dialysance in various dialyzing conditions. |
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Authors:
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N D Vaziri; J Saiki; C H Barton; M Rajudin; R L Ness |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 73 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1980 Apr |
Date Detail:
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Created Date: 1980-06-27 Completed Date: 1980-06-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 422-3 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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blood*,
poisoning Female Humans Middle Aged Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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