Document Detail


Hemodialysis: yesterday, today and tomorrow.
MedLine Citation:
PMID:  20424566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemodialysis was born in 1945 to treat acute renal failure, and it has progressively become a rescue therapy for patients with chronic kidney disease (CKD) stage 5, otherwise doomed to death. During the years, technological innovations have led to improved dialytic tolerance, making possible to extend the treatment to a greater number of subjects. Low- and high-flux bicarbonate dialysis are nowadays the most frequent hemodialysis techniques; hemodiafiltration with different modalities, short daily and overnight hemo-dialysis are also widespread, each of them with peculiar characteristics. A recent randomized controlled clinical trial has identified high-flux hemodialysis as the best treatment for patients with low serum levels of albumin and for diabetics in comparison to low flux dialysis. Apart from the treatment of end-stage renal disease (ESRD), hemodialysis has new and important applications, including heart failure treatment and multiple myeloma. The need to provide hemodialysis patients a better quality of life has increased the interest in developing new techniques, such as the wearable artificial kidney, although still in initial clinical development. During the last 60 years, we have seen an exciting evolution in the field of hemodialysis, which has led to important changes in the outcome of ESRD patients. The preclinical and clinical hard work ongoing in earlier stages of CKD should be able to obtain further relevant improvements and maybe avoid the need of hemodialysis itself.
Authors:
A Cavalli; L Del Vecchio; C Manzoni; F Locatelli
Related Documents :
21518686 - Renal insufficiency following contrast media administration trial ii (remedial ii): ren...
572836 - Eosinophilia in maintenance hemodialysis patients.
20535636 - Erectile dysfunction among hemodialysis patients.
8321366 - Isoniazid-induced neurotoxicity in chronic dialysis patients: report of three cases and...
760406 - Non-invasive assessment of cardiac function in meningitis.
19703836 - Lupus nephritis combined with renal injury due to thrombotic thrombocytopaenic purpura-...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva urologica e nefrologica = The Italian journal of urology and nephrology     Volume:  62     ISSN:  0393-2249     ISO Abbreviation:  Minerva Urol Nefrol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503649     Medline TA:  Minerva Urol Nefrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Dialysis and Renal Transplant, A. Manzoni Hospital, Lecco, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Heart Failure / therapy
Hemodiafiltration / methods*,  trends*
Humans
Kidney Failure, Chronic / therapy*
Multiple Myeloma / therapy
Quality of Life
Randomized Controlled Trials as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The relative toxicity of compounds used as preservatives in vaccines and biologics.
Next Document:  Advances in volume monitoring in dialysis patients.