| Hemodialysis is an independent predictor of coronary in-stent restenosis after paclitaxel eluting stent implantation. | |
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MedLine Citation:
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PMID: 21088337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A drug eluting stent is often used for high-risk patients with complications such as diabetes mellitus (DM) and hemodialysis (HD), however the factors to predict restenosis after paclitaxel-eluting stent (PES) placement have not been reported to date. METHODS: Between May 2007 and August 2009, 165 consecutive patients (231 stents) received PES in our hospital. Stent diameter and length were determined by the use of intravascular ultrasound (IVUS). All patients continued to take 2 types of anti-platelet agents (aspirin and Clopidogrel or Ticlopidine). Ninety percent of the subjects received a follow-up coronary angiogram 6 months later. RESULTS: Underlying diseases were hypertension in 75%, hyperlipidemia in 78% and DM in 60% (15% on insulin), and 14% of the subjects received HD. Eighty-three percent of the patients had orally taken Statin, 85% ACE/ARB and 68% had beta blockers. Mean length and diameter of PES were 21.6 ± 7.2 mm and 2.9 ± 0.3 mm, respectively. Target lesion revascularization (TLR) rate 6 months after PES placement was 14.6% overall. In HD patients TLR was 43%, hypertension 15.0%, hyperlipemia 12.4%, DM with oral medication 12.5%, DM with insulin 12.0%, respectively. In multivariate analysis, HD was an independent risk factor for TLR (p=0.0001, OR: 6.61, 95% C.I.: 2.34-18.6). CONCLUSION: HD had the greatest influence on TLR after PES even though risk factors were well controlled. It is necessary to develop new PCI techniques and stents that are useful for HD patients. |
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Authors:
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Ichiro Takeuchi; Masahiko Moriguchi; Ryuta Imaki; Hidehira Fukaya; Hisahito Shinagawa; Takao Shimohama; Taiki Tojo; Naoto Fukuda; Takayuki Inomata; Naoyoshi Aoyama; Kazui Soma; Tohru Izumi |
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Publication Detail:
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Type: Journal Article Date: 2010-11-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-22 Completed Date: 2011-03-23 Revised Date: 2011-08-17 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 2379-84 Citation Subset: IM |
Affiliation:
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Department of Cardio-Angiology, Kitasato University School of Medicine, Sagamihara, Japan. itake@myad.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Restenosis / epidemiology* Drug-Eluting Stents* Female Humans Male Paclitaxel / administration & dosage* Renal Dialysis* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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33069-62-4/Paclitaxel |
| Comments/Corrections | |
Comment In:
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Intern Med. 2011;50(13):1449-50; author reply 1447 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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