Document Detail

Hemispheric cerebellar rTMS to treat drug-resistant epilepsy: case reports.
MedLine Citation:
PMID:  16426754     Owner:  NLM     Status:  MEDLINE    
Electrical stimulation of the cerebellar cortex by implanted electrodes has been shown to ameliorate refractory epilepsy. We investigated the potential therapeutic role of high-frequency cerebellar rTMS in patients affected by refractory epilepsy due to single or multiple foci. Six patients, three with single and three with multiple epileptic foci, underwent 20 rTMS sessions. Each session was given daily, excluding weekends, and consisted of two trains of 50 stimuli (5 Hz frequency and 90% motor threshold intensity), separated by 50s interval. rTMS was delivered through a focal coil (2 cm below and lateral to the inion) bilaterally in patients with multiple foci (two trains for hemisphere: 100 stimuli each side) and contralaterally to the epileptic focus in the others. Seizure frequency was monitored four weeks before stimulation (pre-rTMS), during the four-week treatment (rTMS) and four weeks after the treatment (post-rTMS). The rTMS over the cerebellar cortex was associated with a significant decrease of rTMS versus pre-rTMS seizure frequency both in patients with single and multiple epileptic foci. However, during the post-rTMS period seizure frequency was back to the pre-rTMS frequency. Although the results are still preliminary, they encourage further studies on larger series of patients. In particular, this rTMS approach, as compared with others, might be more useful in patients with multiple epileptic foci.
Filippo Brighina; Ornella Daniele; Aurelio Piazza; Giuseppe Giglia; Brigida Fierro
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-01-19
Journal Detail:
Title:  Neuroscience letters     Volume:  397     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Neurophysiological Unit, University of Palermo, Institute of Neuropsychiatry, Via G. La Loggia, 1, 90129 Palermo, Italy.
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MeSH Terms
Cerebellar Cortex / physiopathology*
Drug Resistance
Epilepsy / physiopathology,  therapy*
Transcranial Magnetic Stimulation*

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