Document Detail

Hemiparkinsonism-somatic hemiatrophy syndrome.
MedLine Citation:
PMID:  12035843     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This paper highlights the hemiparkinsonism-hemiatrophy (HPHA) syndrome as a unique presentation of the parkinsonian state. Clinically relevant diagnostic and treatment aspects are reviewed. METHOD: We report a case of HPHA, in a 21-year-old, otherwise healthy, woman. Clinical and radiographic features of our case are presented. We also review the current literature on the clinical, radiological and pathophysiological mechanisms of HPHA. RESULTS: In our case, despite the lack of benefit from anticholinergics and dopamine agonists (the patient declined treatment with levodopa), the patient showed a dramatic improvement with subthalamic nucleus stimulator (STN) implantation. There are no reported cases of use of STN stimulator in HPHA. CONCLUSION: Hemiparkinsonism-hemiatrophy is a distinct entity that may be clinically and pathogenetically different from idiopathic Parkinson's disease; hence, HPHA needs to be considered as a possible syndrome in patients that have persistent unilateral parkinsonism. As medications are reported to be unhelpful in HPHA cases, early surgical intervention may be an option, such as in our case.
Mary Jenkins; Dan Mendonca; Andrew Parrent; Mandar S Jog
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  29     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-30     Completed Date:  2002-11-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  184-7     Citation Subset:  IM    
Department of Clinical Neurological Sciences, London Health Sciences Centre, ON, Canada.
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MeSH Terms
Electric Stimulation Therapy*
Facial Hemiatrophy / pathology
Growth Disorders
Musculoskeletal Abnormalities / pathology,  physiopathology
Parkinson Disease / physiopathology*,  therapy*
Subthalamic Nucleus / pathology,  physiopathology
Tremor / etiology,  physiopathology,  therapy

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