Document Detail

Hemin inhibits transfer of pre-delta-aminolevulinate synthase into chick embryo liver mitochondria.
MedLine Citation:
PMID:  6661228     Owner:  NLM     Status:  MEDLINE    
Pulse labelling studies in chick embryo livers show that hemin prevents the transfer of drug induced pre-delta-aminolevulinate synthase from the cytosol into the mitochondria, leading to an accumulation of precursor in the cytosol. No effect of hemin was observed on the transfer of pre-pyruvate carboxylase into mitochondria. These results eliminated a general toxic effect of hemin on mitochondrial import of proteins and are consistent with the view that hemin specifically inhibits the transfer of ALA synthase.
G Srivastava; I A Borthwick; J D Brooker; J C Wallace; B K May; W H Elliott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  117     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-20     Completed Date:  1984-02-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  344-9     Citation Subset:  IM    
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MeSH Terms
5-Aminolevulinate Synthetase / genetics*
Chick Embryo
Cytosol / enzymology
Enzyme Precursors / genetics*
Heme / pharmacology*
Liver / enzymology
Mitochondria, Liver / enzymology*
Molecular Weight
Protein Processing, Post-Translational / drug effects*
Pyruvate Carboxylase / genetics
Reg. No./Substance:
0/Enzyme Precursors; 14875-96-8/Heme; EC Synthetase; EC Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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