Document Detail

Hemin, inducer of heme-oxygenase 1, improves functional recovery from myocardial stunning in conscious dogs.
MedLine Citation:
PMID:  11505343     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effects of pretreatment with hemin, an inducer of the potential antioxidative enzyme heme-oxygenase 1 (HO-1) or heat-shock protein 32, on myocardial stunning. DESIGN: Randomized animal study. SETTING: Animal laboratory of a university hospital. PARTICIPANTS: Chronically instrumented mongrel dogs (n = 44). INTERVENTIONS: Dogs underwent chronic instrumentation for measurement of hemodynamics and myocardial wall thickening fraction (WTF). Experiments with 12 dogs were performed on separate days in a crossover fashion: (1) 10 minutes of left anterior descending (LAD) coronary artery occlusion after application of hemin (9 mg/kg/d) for 1 week and (2) 10 minutes of LAD coronary artery occlusion without hemin pretreatment. In control experiments (n = 32), the reversible induction of HO-1, using gel electrophoresis and Western blotting, was determined. MEASUREMENTS AND MAIN RESULTS: WTF was measured as a baseline value before hemin administration and at predetermined time points until complete recovery from stunning. LAD artery occlusion caused a significant reduction in the WTF in the LAD-perfused area with and without hemin, without significant hemodynamic changes. At all time points, after 1 minute of reperfusion, the WTF as percentage of baseline values was significantly higher after hemin pretreatment (p < 0.05). Baseline WTF values were reached after 24 hours with and after >48 hours without hemin pretreatment (p < 0.05). CONCLUSION: Hemin pretreatment attenuates myocardial stunning in conscious dogs.
T P Weber; A Meissner; P Boknik; M G Hartlage; T Möllhoff; H Van Aken; N Rolf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  15     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-15     Completed Date:  2001-09-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company.
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, and Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, Münster, Germany.
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MeSH Terms
Blood Flow Velocity
Coronary Circulation
Coronary Vessels / enzymology
Heme Oxygenase (Decyclizing) / biosynthesis*
Heme Oxygenase-1
Hemin / administration & dosage,  pharmacology,  therapeutic use*
Myocardial Contraction
Myocardial Reperfusion
Myocardial Stunning / drug therapy,  enzymology,  physiopathology*
Ultrasonography, Doppler, Pulsed
Ventricular Pressure
Reg. No./Substance:
16009-13-5/Hemin; EC Oxygenase (Decyclizing); EC Oxygenase-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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