| Hemin, inducer of heme-oxygenase 1, improves functional recovery from myocardial stunning in conscious dogs. | |
| | |
MedLine Citation:
|
PMID: 11505343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the effects of pretreatment with hemin, an inducer of the potential antioxidative enzyme heme-oxygenase 1 (HO-1) or heat-shock protein 32, on myocardial stunning. DESIGN: Randomized animal study. SETTING: Animal laboratory of a university hospital. PARTICIPANTS: Chronically instrumented mongrel dogs (n = 44). INTERVENTIONS: Dogs underwent chronic instrumentation for measurement of hemodynamics and myocardial wall thickening fraction (WTF). Experiments with 12 dogs were performed on separate days in a crossover fashion: (1) 10 minutes of left anterior descending (LAD) coronary artery occlusion after application of hemin (9 mg/kg/d) for 1 week and (2) 10 minutes of LAD coronary artery occlusion without hemin pretreatment. In control experiments (n = 32), the reversible induction of HO-1, using gel electrophoresis and Western blotting, was determined. MEASUREMENTS AND MAIN RESULTS: WTF was measured as a baseline value before hemin administration and at predetermined time points until complete recovery from stunning. LAD artery occlusion caused a significant reduction in the WTF in the LAD-perfused area with and without hemin, without significant hemodynamic changes. At all time points, after 1 minute of reperfusion, the WTF as percentage of baseline values was significantly higher after hemin pretreatment (p < 0.05). Baseline WTF values were reached after 24 hours with and after >48 hours without hemin pretreatment (p < 0.05). CONCLUSION: Hemin pretreatment attenuates myocardial stunning in conscious dogs. |
| | |
Authors:
|
T P Weber; A Meissner; P Boknik; M G Hartlage; T Möllhoff; H Van Aken; N Rolf |
Related Documents
:
|
19379203 - Noninvasive monitoring of doxorubicin cardiotoxicity: a pilot study of two dogs. 8193993 - Effect of parathyroid hormone on myocardial bloodflow and infarct size following corona... 11499753 - Pressure rinsing of coronary stents immediately before implantation reduces inflammatio... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiothoracic and vascular anesthesia Volume: 15 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 2001 Aug |
Date Detail:
|
Created Date: 2001-08-15 Completed Date: 2001-09-27 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: United States |
Other Details:
|
Languages: eng Pagination: 422-7 Citation Subset: IM |
Copyright Information:
|
Copyright 2001 by W.B. Saunders Company. |
Affiliation:
|
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, and Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, Münster, Germany. weber@anit.uni-muenster.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Flow Velocity Coronary Circulation Coronary Vessels / enzymology Dogs Heme Oxygenase (Decyclizing) / biosynthesis* Heme Oxygenase-1 Hemin / administration & dosage, pharmacology, therapeutic use* Myocardial Contraction Myocardial Reperfusion Myocardial Stunning / drug therapy, enzymology, physiopathology* Premedication Ultrasonography, Doppler, Pulsed Ventricular Pressure |
| Chemical | |
Reg. No./Substance:
|
16009-13-5/Hemin; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does isoflurane optimize myocardial protection during cardiopulmonary bypass?
Next Document: Impact of off-pump coronary artery surgery on myocardial performance and beta-adrenoceptor function.