| Hemicraniectomy: a new model for human electrophysiology with high spatio-temporal resolution. | |
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MedLine Citation:
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PMID: 19925193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human electrophysiological research is generally restricted to scalp EEG, magneto-encephalography, and intracranial electrophysiology. Here we examine a unique patient cohort that has undergone decompressive hemicraniectomy, a surgical procedure wherein a portion of the calvaria is removed for several months during which time the scalp overlies the brain without intervening bone. We quantify the differences in signals between electrodes over areas with no underlying skull and scalp EEG electrodes over the intact skull in the same subjects. Signals over the hemicraniectomy have enhanced amplitude and greater task-related power at higher frequencies (60-115 Hz) compared with signals over skull. We also provide evidence of a metric for trial-by-trial EMG/EEG coupling that is effective over the hemicraniectomy but not intact skull at frequencies >60 Hz. Taken together, these results provide evidence that the hemicraniectomy model provides a means for studying neural dynamics in humans with enhanced spatial and temporal resolution. |
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Authors:
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Bradley Voytek; Lavi Secundo; Aurelie Bidet-Caulet; Donatella Scabini; Shirley I Stiver; Alisa D Gean; Geoffrey T Manley; Robert T Knight |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cognitive neuroscience Volume: 22 ISSN: 1530-8898 ISO Abbreviation: J Cogn Neurosci Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-11-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8910747 Medline TA: J Cogn Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 2491-502 Citation Subset: IM |
Affiliation:
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Helen Wills Neuroscience, University of California, Berkeley, Berkeley, CA 94720-3190, USA. bradley.voytek@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Blinking / physiology Brain Injuries / physiopathology, surgery Brain Mapping* Cerebral Cortex / physiology*, surgery Decompressive Craniectomy / methods Electroencephalography* Electromyography / methods Evoked Potentials, Auditory / physiology Female Fourier Analysis Functional Laterality / physiology* Humans Image Processing, Computer-Assisted / methods Intracranial Pressure / physiology Male Movement / physiology Scalp Time Factors Tomography, X-Ray Computed / methods |
| Grant Support | |
ID/Acronym/Agency:
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5-T32-MH18882/MH/NIMH NIH HHS; NS050173/NS/NINDS NIH HHS; NS21135/NS/NINDS NIH HHS; NS21135-22S1/NS/NINDS NIH HHS; R01 NS021135-22/NS/NINDS NIH HHS; R01 NS021135-22S1/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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