| Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain. | |
| | |
MedLine Citation:
|
PMID: 18211622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The patient's hemichorea decreased gradually after cessation of gabapentin. The study of rCBF revealed hypoperfusion in the contralateral basal ganglia compared with the previous study of rCBF. Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions. Imaging studies of rCBF showed a perfusion defect in the contralateral basal ganglion. |
| | |
Authors:
|
M-H Lai; T-Y Wang; C-C Chang; K-C Tsai; S-T Chang |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of clinical pharmacy and therapeutics Volume: 33 ISSN: 1365-2710 ISO Abbreviation: J Clin Pharm Ther Publication Date: 2008 Feb |
Date Detail:
|
Created Date: 2008-01-23 Completed Date: 2008-03-31 Revised Date: 2008-05-28 |
Medline Journal Info:
|
Nlm Unique ID: 8704308 Medline TA: J Clin Pharm Ther Country: England |
Other Details:
|
Languages: eng Pagination: 83-6 Citation Subset: IM |
Affiliation:
|
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amines / adverse effects* Analgesics / adverse effects* Basal Ganglia / blood supply, drug effects* Cerebrovascular Circulation / drug effects Chorea / chemically induced* Cyclohexanecarboxylic Acids / adverse effects* Humans Male Neuralgia / drug therapy* Paraplegia Tomography, Emission-Computed, Single-Photon gamma-Aminobutyric Acid / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 60142-96-3/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in...
Next Document: Sublingual administration of tacrolimus in a renal transplant patient.