Document Detail


Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain.
MedLine Citation:
PMID:  18211622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The patient's hemichorea decreased gradually after cessation of gabapentin. The study of rCBF revealed hypoperfusion in the contralateral basal ganglia compared with the previous study of rCBF. Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions. Imaging studies of rCBF showed a perfusion defect in the contralateral basal ganglion.
Authors:
M-H Lai; T-Y Wang; C-C Chang; K-C Tsai; S-T Chang
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacy and therapeutics     Volume:  33     ISSN:  1365-2710     ISO Abbreviation:  J Clin Pharm Ther     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-23     Completed Date:  2008-03-31     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8704308     Medline TA:  J Clin Pharm Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amines / adverse effects*
Analgesics / adverse effects*
Basal Ganglia / blood supply,  drug effects*
Cerebrovascular Circulation / drug effects
Chorea / chemically induced*
Cyclohexanecarboxylic Acids / adverse effects*
Humans
Male
Neuralgia / drug therapy*
Paraplegia
Tomography, Emission-Computed, Single-Photon
gamma-Aminobutyric Acid / adverse effects*
Chemical
Reg. No./Substance:
0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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