| Hemi-parkinsonism in multiple system atrophy: a PET and MRI study. | |
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MedLine Citation:
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PMID: 1506867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We selected 6 patients presenting with hemi-parkinsonism from a total of 20 patients with probable multiple system atrophy (MSA) and studied their nigrostriatal lesions using magnetic resonance (MR) imaging and positron emission tomography (PET) with 18F-labeled 2-deoxy-2-fluoro-D-glucose (FDG). T2 weighted MR images demonstrated a decreased signal intensity in the putamen of all patients. This decreased signal was more intense in the nucleus contralateral to the affected body side in 5 patients. A decreased signal in the substantia nigra was found, expanding more on the contralateral side in 3 patients. T1-weighted images showed that the contralateral putamen was smaller in size than the ipsilateral. These findings indicated that the iron deposit and the neuronal cell loss in the degenerative process were more remarkable in the contralateral nuclei. FDG uptake in 5 patients had likewise declined more in the contralateral than in the ipsilateral putamen. The study shows that these patients have the nigrostriatal lesions as described in previous reports on MSA and that an asymmetric lesion relating to clinical signs is present in the nigrostriatal system. When a patient presents with hemi-parkinsonism alone, MR imaging and PET/FDG are useful for the clinical diagnosis of MSA. |
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Authors:
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A Kume; M Shiratori; A Takahashi; T Kato; K Ito; M Tadokoro; S Sakuma |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 110 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-09-23 Completed Date: 1992-09-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 37-45 Citation Subset: IM |
Affiliation:
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Department of Neurology, Nagoya University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrophy Deoxyglucose / analogs & derivatives, diagnostic use Female Fluorine Radioisotopes / diagnostic use Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Middle Aged Organ Specificity Parkinson Disease / pathology*, radionuclide imaging Reference Values Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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