Document Detail

Heme synthesis in the lead-intoxicated mouse embryo.
MedLine Citation:
PMID:  653737     Owner:  NLM     Status:  MEDLINE    
Incorporation of 55Fe and of [14C]glycine was studied in control embryos and mothers and in those which had received lead in the diet from day 7 of pregnancy. Incorporation of Fe into heme of embryonic liver which increases markedly for controls on day 17 of pregnancy was depressed greatly and showed no such increase in lead-intoxicated embryos. These embryos were retarded in growth but had normal heme concentrations in body and liver. Incorporation of glycine into embryonic heme and proteins was not affected. Data on incorporation in the mothers are also presented. It is thought that the impaired synthesis of heme in lead-intoxicated embryos limits their body growth during the late phase of pregnancy.
G B Gerber; J Maes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  9     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
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MeSH Terms
Embryo, Mammalian / metabolism*
Gestational Age
Heme / biosynthesis*
Iron Radioisotopes / diagnostic use
Lead Poisoning / metabolism*
Liver / embryology,  metabolism
Maternal-Fetal Exchange
Mice, Inbred C57BL
Protein Biosynthesis
Reg. No./Substance:
0/Iron Radioisotopes; 14875-96-8/Heme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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