| Heme synthesis in the lead-intoxicated mouse embryo. | |
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MedLine Citation:
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PMID: 653737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Incorporation of 55Fe and of [14C]glycine was studied in control embryos and mothers and in those which had received lead in the diet from day 7 of pregnancy. Incorporation of Fe into heme of embryonic liver which increases markedly for controls on day 17 of pregnancy was depressed greatly and showed no such increase in lead-intoxicated embryos. These embryos were retarded in growth but had normal heme concentrations in body and liver. Incorporation of glycine into embryonic heme and proteins was not affected. Data on incorporation in the mothers are also presented. It is thought that the impaired synthesis of heme in lead-intoxicated embryos limits their body growth during the late phase of pregnancy. |
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Authors:
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G B Gerber; J Maes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology Volume: 9 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-07-15 Completed Date: 1978-07-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 173-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryo, Mammalian / metabolism* Female Gestational Age Heme / biosynthesis* Iron Radioisotopes / diagnostic use Lead Poisoning / metabolism* Liver / embryology, metabolism Male Maternal-Fetal Exchange Mice Mice, Inbred C57BL Pregnancy Protein Biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Iron Radioisotopes; 14875-96-8/Heme |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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