Document Detail


The Heme oxygenases: Important regulators of pregnancy and preeclampsia.
MedLine Citation:
PMID:  24898840     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The heme oxygenase system has long been believed to act largely as a housekeeping unit, converting pro-oxidant free heme from heme protein degradation into the benign bilirubin for conjugation and safe excretion. Recently, however, heme oxygenase have emerged as important regulators of cardiovascular function, largely through the production of their biologically active metabolites: carbon monoxide, bilirubin, and elemental iron. Even more recently, a number of separate lines of evidence have demonstrated an important role for the heme oxygenases in the establishment and maintenance of pregnancy. Early preclinical and clinical studies have associated defects in the heme oxygenase with the obstetrical complication preeclampsia, and failure to establish adequate placental blood flow-an underlying mechanism of the disorder. Several recent preclinical studies have suggested, however, that the heme oxygenase system could serve as a valuable therapeutic for the management of preeclampsia, which currently has little in the way of pharmacological options. This review will summarize the role of heme oxygenases in pregnancy, and highlight their potential in advancing the management of the preeclampsia patient.
Authors:
Eric M George; Junie Paula Warrington; Frank T Spradley; Ana Carolina Palei; Joey P Granger
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-4
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
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