Document Detail


Heme oxygenase in pregnancy and preeclampsia.
MedLine Citation:
PMID:  23328500     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field.
RECENT FINDINGS: New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that the heme oxygenase system is an important regulator of placental development, particularly in vascular structure. Furthermore, emerging studies demonstrate a role for heme oxygenase in the maintenance of pregnancy, especially during pathological challenge. Intriguingly, it now appears that the heme oxygenase system can be dramatically altered by pathological disorders of pregnancy, in particular preeclampsia, perhaps functionally in the symptomatic phase of the disorder. Promisingly, however, recent data suggest that induction of the heme oxygenase system, or administration of its bioactive metabolites, could provide a promising novel therapeutic approach to the management of this currently untreatable disease.
SUMMARY: Long considered a molecular housekeeping system, the heme oxygenase system is now known to be an important stress response pathway. New evidence suggests that it is also an important player in pregnancy and preeclampsia. However, the evidence now also suggests that it may provide a therapeutic approach for this common disease with few management options.
Authors:
Eric M George; Joey P Granger
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  22     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-26     Revised Date:  2014-11-07    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bilirubin / metabolism
Blood Pressure
Carbon Monoxide / metabolism
Female
Heme Oxygenase (Decyclizing) / metabolism*
Humans
Placenta / enzymology*
Pre-Eclampsia / enzymology*,  physiopathology,  therapy
Pregnancy
Signal Transduction
Grant Support
ID/Acronym/Agency:
1T32HL105324-01/HL/NHLBI NIH HHS; HL105324-01/HL/NHLBI NIH HHS; HL108618-01/HL/NHLBI NIH HHS; HL51971/HL/NHLBI NIH HHS; P01 HL051971/HL/NHLBI NIH HHS; R01 HL108618/HL/NHLBI NIH HHS; T32 HL105324/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7U1EE4V452/Carbon Monoxide; EC 1.14.99.3/Heme Oxygenase (Decyclizing); RFM9X3LJ49/Bilirubin
Comments/Corrections

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