| Heme oxygenase in pregnancy and preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 23328500 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field. RECENT FINDINGS: New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that the heme oxygenase system is an important regulator of placental development, particularly in vascular structure. Furthermore, emerging studies demonstrate a role for heme oxygenase in the maintenance of pregnancy, especially during pathological challenge. Intriguingly, it now appears that the heme oxygenase system can be dramatically altered by pathological disorders of pregnancy, in particular preeclampsia, perhaps functionally in the symptomatic phase of the disorder. Promisingly, however, recent data suggest that induction of the heme oxygenase system, or administration of its bioactive metabolites, could provide a promising novel therapeutic approach to the management of this currently untreatable disease. SUMMARY: Long considered a molecular housekeeping system, the heme oxygenase system is now known to be an important stress response pathway. New evidence suggests that it is also an important player in pregnancy and preeclampsia. However, the evidence now also suggests that it may provide a therapeutic approach for this common disease with few management options. |
| | |
Authors:
|
Eric M George; Joey P Granger |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-16 |
Journal Detail:
|
Title: Current opinion in nephrology and hypertension Volume: - ISSN: 1535-3842 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology and Biophysics, Center for Excellence in Cardiovascular Research, The University of Mississippi Medical Center, Jackson, Mississippi, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Tacrolimus on the Pharmacokinetics and Glucuronidation of SN-38, an Active Metabolite of I...
Next Document: Update on the treatment of lupus nephritis.