| Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis. | |
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MedLine Citation:
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PMID: 11435909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease, multiple sclerosis (MS). Heme oxygenase-1 (HO-1) is a heat shock protein induced by oxidative stress. HO-1 metabolizes heme to the antioxidant bilirubin and carbon monoxide, and represents a powerful endogenous defensive mechanism against free radicals in many diseases. However, the role of this important enzyme in EAE remains unknown. In this study, we showed high expression of HO-1 in lesions of EAE, and demonstrated that hemin, an inducer of HO-1, inhibited EAE effectively. In contrast, tin mesoporphyrin, an inhibitor of HO-1, markedly exacerbated EAE. Our results suggest that endogenous HO-1 plays an important protective role in EAE, and that targeted induction of HO-1 overexpression may represent a new therapy for the treatment of multiple sclerosis. |
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Authors:
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Y Liu; B Zhu; L Luo; P Li; D W Paty; M S Cynader |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 12 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-03 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1841-5 Citation Subset: IM |
Affiliation:
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Brain Research Center, University of British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Encephalomyelitis, Autoimmune, Experimental / drug therapy, enzymology*, physiopathology Enzyme Inhibitors / pharmacology Heme Oxygenase (Decyclizing) / drug effects, metabolism* Heme Oxygenase-1 Hemin / pharmacology Immunohistochemistry Lymph Nodes / cytology, drug effects, enzymology Macrophages / cytology, drug effects, enzymology Male Metalloporphyrins / pharmacology Multiple Sclerosis / drug therapy, enzymology*, physiopathology Neuroprotective Agents / pharmacology Oxidative Stress / drug effects, physiology* Rats Rats, Inbred Lew Spinal Cord / drug effects, enzymology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Metalloporphyrins; 0/Neuroprotective Agents; 106344-20-1/tin mesoporphyrin; 16009-13-5/Hemin; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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