Document Detail

Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis.
MedLine Citation:
PMID:  11435909     Owner:  NLM     Status:  MEDLINE    
Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease, multiple sclerosis (MS). Heme oxygenase-1 (HO-1) is a heat shock protein induced by oxidative stress. HO-1 metabolizes heme to the antioxidant bilirubin and carbon monoxide, and represents a powerful endogenous defensive mechanism against free radicals in many diseases. However, the role of this important enzyme in EAE remains unknown. In this study, we showed high expression of HO-1 in lesions of EAE, and demonstrated that hemin, an inducer of HO-1, inhibited EAE effectively. In contrast, tin mesoporphyrin, an inhibitor of HO-1, markedly exacerbated EAE. Our results suggest that endogenous HO-1 plays an important protective role in EAE, and that targeted induction of HO-1 overexpression may represent a new therapy for the treatment of multiple sclerosis.
Y Liu; B Zhu; L Luo; P Li; D W Paty; M S Cynader
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  12     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1841-5     Citation Subset:  IM    
Brain Research Center, University of British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada.
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MeSH Terms
Encephalomyelitis, Autoimmune, Experimental / drug therapy,  enzymology*,  physiopathology
Enzyme Inhibitors / pharmacology
Heme Oxygenase (Decyclizing) / drug effects,  metabolism*
Heme Oxygenase-1
Hemin / pharmacology
Lymph Nodes / cytology,  drug effects,  enzymology
Macrophages / cytology,  drug effects,  enzymology
Metalloporphyrins / pharmacology
Multiple Sclerosis / drug therapy,  enzymology*,  physiopathology
Neuroprotective Agents / pharmacology
Oxidative Stress / drug effects,  physiology*
Rats, Inbred Lew
Spinal Cord / drug effects,  enzymology,  physiopathology
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Metalloporphyrins; 0/Neuroprotective Agents; 106344-20-1/tin mesoporphyrin; 16009-13-5/Hemin; EC Oxygenase (Decyclizing); EC Oxygenase-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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