Document Detail


Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis.
MedLine Citation:
PMID:  11435909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease, multiple sclerosis (MS). Heme oxygenase-1 (HO-1) is a heat shock protein induced by oxidative stress. HO-1 metabolizes heme to the antioxidant bilirubin and carbon monoxide, and represents a powerful endogenous defensive mechanism against free radicals in many diseases. However, the role of this important enzyme in EAE remains unknown. In this study, we showed high expression of HO-1 in lesions of EAE, and demonstrated that hemin, an inducer of HO-1, inhibited EAE effectively. In contrast, tin mesoporphyrin, an inhibitor of HO-1, markedly exacerbated EAE. Our results suggest that endogenous HO-1 plays an important protective role in EAE, and that targeted induction of HO-1 overexpression may represent a new therapy for the treatment of multiple sclerosis.
Authors:
Y Liu; B Zhu; L Luo; P Li; D W Paty; M S Cynader
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  12     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1841-5     Citation Subset:  IM    
Affiliation:
Brain Research Center, University of British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Encephalomyelitis, Autoimmune, Experimental / drug therapy,  enzymology*,  physiopathology
Enzyme Inhibitors / pharmacology
Heme Oxygenase (Decyclizing) / drug effects,  metabolism*
Heme Oxygenase-1
Hemin / pharmacology
Immunohistochemistry
Lymph Nodes / cytology,  drug effects,  enzymology
Macrophages / cytology,  drug effects,  enzymology
Male
Metalloporphyrins / pharmacology
Multiple Sclerosis / drug therapy,  enzymology*,  physiopathology
Neuroprotective Agents / pharmacology
Oxidative Stress / drug effects,  physiology*
Rats
Rats, Inbred Lew
Spinal Cord / drug effects,  enzymology,  physiopathology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Metalloporphyrins; 0/Neuroprotective Agents; 106344-20-1/tin mesoporphyrin; 16009-13-5/Hemin; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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