| Heme oxygenase-1 genotype is a vascular anti-inflammatory factor following balloon angioplasty. | |
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MedLine Citation:
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PMID: 12222997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the association of the heme oxygenase-1 (HO-1) genotype, which has potent anti-inflammatory capability, and the inflammatory response induced by balloon angioplasty. METHODS: Three hundred seventeen patients (188 men; median age 70 years, range 57-77) undergoing femoropopliteal balloon angioplasty (n=150) or stenting (n=61) were evaluated for upregulation of the HO-1 genotype; 106 patients undergoing lower limb angiography served as controls. The acute phase reactants C-reactive protein (CRP), serum amyloid A (SAA), and fibrinogen were measured 24 and 48 hours postintervention and compared to baseline values. An association of the relative increase (Delta, %) of these inflammatory markers with short (<25) (GT)(n) dinucleotide repeats in the HO-1 gene promoter was assessed. RESULTS: The HO-1 genotype was significantly associated with Delta CRP(24) (p<0.0001), Delta CRP(48) (p<0.0001), Delta SAA(24) (p=0.02), and Delta SAA(48) (p=0.006) after balloon angioplasty; Delta fibrinogen showed no association. Patients with a higher Delta CRP(48) after balloon angioplasty exhibited significantly reduced odds for the presence of short (<25) (GT)(n) repeats. The adjusted odds reduction in the multivariate model was 80% (p=0.002) in the third quartile of Delta CRP(48) values and 90% (p=0.001) in the fourth quartile. No association of HO-1 genotype and inflammatory response was found 24 and 48 hours after stenting (p=0.3, p=0.5) or angiography (p=0.2, p=0.6). CONCLUSIONS: The HO-1 promoter genotype is independently associated with the inflammatory response seen after balloon angioplasty. Short alleles (<25 GT repeats) seem to be an intrinsic vascular anti-inflammatory factor. |
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Authors:
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Martin Schillinger; Markus Exner; Wolfgang Mlekusch; Ramazanali Ahmadi; Helmut Rumpold; Christine Mannhalter; Oswald Wagner; Erich Minar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 9 ISSN: 1526-6028 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-11 Completed Date: 2002-12-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 385-94 Citation Subset: IM |
Affiliation:
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Department of Angiology, University of Vienna Medical School, Vienna, Austria. martin.schillinger@akh-wien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon* Apolipoproteins / blood* C-Reactive Protein / analysis* Female Femoral Artery Fibrinogen / analysis Genotype Heme Oxygenase (Decyclizing) / genetics* Heme Oxygenase-1 Humans Inflammation / genetics Male Membrane Proteins Microsatellite Repeats / genetics Middle Aged Popliteal Artery Promoter Regions, Genetic Prospective Studies Serum Amyloid A Protein Stents Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Membrane Proteins; 0/Serum Amyloid A Protein; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC 1.14.99.3/HMOX1 protein, human; EC 1.14.99.3/Heme Oxygenase (Decyclizing); EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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