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Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting.
MedLine Citation:
PMID:  17400606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Gene expression analyses, cell culture experiments, animal models, and association studies suggest a protective role of the heme oxygenase-1 (HO-1) protein against restenosis. The length of a polymorphic (GT)n dinucleotid repeats sequence in the HO-1 gene promoter influences the transcriptional activity. We evaluated, whether an association existed between this polymorphism and the incidence of restenosis after coronary stenting. METHODS AND RESULTS: Of the 1807 consecutive patients included in this study, 1357 (75%) patients had 6 months follow-up angiography. Restenosis, the primary endpoint, was defined as angiographic restenosis, diameter stenosis of > or =50%, and clinical restenosis, target vessel revascularization during the first year. The combined 1 year incidence of death and myocardial infarction (MI) was evaluated as secondary endpoint. We divided the alleles similar to previous studies: class S less repeats (<25), and class L more repeats (> or =25), leading to SS, SL, and LL genotypes. Angiographic restenosis rate showed no significant difference for the studied genotypes-SS 29.2%, SL 29.5%, and LL genotype 29.6% (P = 0.99). There was no significant difference regarding clinical restenosis (P = 0.28) and combined incidence of death or MI (P = 0.98). CONCLUSION: This study does not support a clinically relevant association of the HO-1 promoter polymorphism with restenosis and ischaemic events after coronary stenting.
Authors:
Klaus Tiroch; Werner Koch; Nikolas von Beckerath; Adnan Kastrati; Albert Schömig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-30
Journal Detail:
Title:  European heart journal     Volume:  28     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  968-73     Citation Subset:  IM    
Affiliation:
Deutsches Herzzentrum München, 1. Medizinische Klinik Rechts der Isar, Technische Universität München, Lazarettstrasse 36, München D-80636, Germany. klaustiroch@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
C-Reactive Protein / metabolism
Coronary Angiography
Coronary Restenosis / genetics*,  prevention & control,  radiography
Female
Genotype
Heme Oxygenase-1 / genetics*
Humans
Male
Myocardial Infarction / etiology
Polymorphism, Genetic / genetics*
Postoperative Complications / etiology
Stents*
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein; EC 1.14.99.3/Heme Oxygenase-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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