| Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. | |
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MedLine Citation:
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PMID: 17400606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Gene expression analyses, cell culture experiments, animal models, and association studies suggest a protective role of the heme oxygenase-1 (HO-1) protein against restenosis. The length of a polymorphic (GT)n dinucleotid repeats sequence in the HO-1 gene promoter influences the transcriptional activity. We evaluated, whether an association existed between this polymorphism and the incidence of restenosis after coronary stenting. METHODS AND RESULTS: Of the 1807 consecutive patients included in this study, 1357 (75%) patients had 6 months follow-up angiography. Restenosis, the primary endpoint, was defined as angiographic restenosis, diameter stenosis of > or =50%, and clinical restenosis, target vessel revascularization during the first year. The combined 1 year incidence of death and myocardial infarction (MI) was evaluated as secondary endpoint. We divided the alleles similar to previous studies: class S less repeats (<25), and class L more repeats (> or =25), leading to SS, SL, and LL genotypes. Angiographic restenosis rate showed no significant difference for the studied genotypes-SS 29.2%, SL 29.5%, and LL genotype 29.6% (P = 0.99). There was no significant difference regarding clinical restenosis (P = 0.28) and combined incidence of death or MI (P = 0.98). CONCLUSION: This study does not support a clinically relevant association of the HO-1 promoter polymorphism with restenosis and ischaemic events after coronary stenting. |
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Authors:
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Klaus Tiroch; Werner Koch; Nikolas von Beckerath; Adnan Kastrati; Albert Schömig |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-30 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 968-73 Citation Subset: IM |
Affiliation:
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Deutsches Herzzentrum München, 1. Medizinische Klinik Rechts der Isar, Technische Universität München, Lazarettstrasse 36, München D-80636, Germany. klaustiroch@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged C-Reactive Protein / metabolism Coronary Angiography Coronary Restenosis / genetics*, prevention & control, radiography Female Genotype Heme Oxygenase-1 / genetics* Humans Male Myocardial Infarction / etiology Polymorphism, Genetic / genetics* Postoperative Complications / etiology Stents* |
| Chemical | |
Reg. No./Substance:
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9007-41-4/C-Reactive Protein; EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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