Document Detail


Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology.
MedLine Citation:
PMID:  25344086     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Activation of heme oxygenase-1 (HO-1), a heme-degrading enzyme responsive to a wide range of cellular stress, is traditionally considered to convey adaptive responses to oxidative stress, inflammation and vasoconstriction. These diversified effects are achieved through the degradation of heme to carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin by biliverdin reductase) and ferric iron. Recent findings have added antiproliferative and angiogenic effects to the list of HO-1/CO actions. HO-1 along with its reaction products bilirubin and CO are protective against ischemia-induced injury (myocardial infarction, ischemia-reperfusion (IR)-injury and post-infarct structural remodelling). Moreover, HO-1, and CO in particular, possess acute antihypertensive effects. As opposed to these curative potentials, the long-believed protective effect of HO-1 in cardiac remodelling in response to pressure overload and type 2 diabetes mellitus (DM) has been questioned by recent work. These challenges, coupled with emerging regulatory mechanisms, motivate further in-depth studies to help understand untapped layers of HO-1 regulation and action. The outcomes of these efforts may shed new light on critical mechanisms that could be used to harness the protective potential of this enzyme for the therapeutic benefit of patients suffering from such highly prevalent cardiovascular disorders.
Authors:
Gabor Czibik; Geneviéve Derumeaux; Daigo Sawaki; Guro Valen; Roberto Motterlini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-25
Journal Detail:
Title:  Basic research in cardiology     Volume:  109     ISSN:  1435-1803     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-10-25     Completed Date:  -     Revised Date:  2014-10-26    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  450     Citation Subset:  -    
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