| Heme Oxygenase-1/CO as Protective Mediators in Cigarette Smoke-Induced Lung Cell Injury and Chronic Obstructive Pulmonary Disease. | |
| | |
MedLine Citation:
|
PMID: 22201606 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Chronic obstructive pulmonary disease (COPD) is a disease involving airways restriction, alveolar destruction, and loss of lung function, primarily due to cigarette smoke (CS) exposure. The inducible stress protein heme oxygenase-1 (HO-1) has been implicated in cytoprotection against the toxic action of many xenobiotics, including CS. HO-1 also protects against elastase-induced emphysema. Differential expression of HO-1 in epithelial cells and macrophages may contribute to COPD susceptibility. Genetic polymorphisms in the HO-1 gene, which may account for variations in HO-1 expression among subpopulations, may be associated with COPD pathogenesis. Carbon monoxide (CO), a primary reaction product of HO-1 has been implicated in cytoprotection in many acute lung injury models, though it's precise role in chronic CS-induced lung injury remains unclear. CO is a potential biomarker of CS exposure and of inflammatory lung conditions. To date, a single clinical trial has addressed the possible therapeutic potential of CO in COPD patients. The implications of the cytoprotective potential of HO-1/CO system in CS-induced lung injury and COPD are discussed. |
| | |
Authors:
|
Tamás Dolinay; Augustine Mk Choi; Stefan W Ryter |
Related Documents
:
|
22189406 - Anticancer effects of imperatorin isolated from angelica dahurica: induction of apoptos... 21659536 - Distinct roles for nod2 and autocrine il-1{beta} in mdp-induced mapk activation and cyt... 21787626 - Tanghinigenin from seeds of cerbera manghas l. induces apoptosis in human promyelocytic... 22211786 - Cytokines produced by microwave-radiated sertoli cells interfere with spermatogenesis i... 19782086 - Carbamylated darbepoetin derivative prevents endothelial progenitor cell damage with no... 11849316 - Murine graft-versus-host disease induced using interferon-gamma-deficient grafts featur... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-1 |
Journal Detail:
|
Title: Current pharmaceutical biotechnology Volume: - ISSN: 1873-4316 ISO Abbreviation: - Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. sryter@partners.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of Carbon Monoxide in Kidney Function: Is a little Carbon Monoxide Good for the Kidney?
Next Document: Carbon Monoxide In Acute Lung Injury.