Document Detail

Hematoporphyrin derivative binding and photosensitization in human glioblastoma cells: comparison of exponential and plateau phase cells.
MedLine Citation:
PMID:  7896304     Owner:  NLM     Status:  MEDLINE    
Plateau phase glioblastoma (U 87MG) cells were found more photosensitive than the exponentially growing cells. In both phases of growth, the photosensitivity showed further enhancement on incubating the cells with HpD for longer duration. Plateau phase cells accumulated more HpD than exponential phase cells for shorter duration of incubation with HpD, however, for longer duration of incubation, the amount of drug uptake was almost the same in both phases of growth. Fluorescence spectra of cell bound HpD showed a difference in spectral intensity distribution in exponential and plateau phase cells. In exponential phase cells, the fluorescence maximum of cell bound HpD was at 615 nm whereas in plateau phase cells the same was at 636 nm.
R Sreenivasan; P G Joshi; N B Joshi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  32     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  763-6     Citation Subset:  IM    
Department of Biophysics, National Institute of Mental Health and Neuro Science, Bangalore, India.
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MeSH Terms
Brain Neoplasms / metabolism*,  pathology
Cell Cycle / physiology
Glioblastoma / metabolism*,  pathology
Hematoporphyrin Derivative / metabolism*
Reg. No./Substance:
68335-15-9/Hematoporphyrin Derivative

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