| Hematopoietic stem cell transplantation for bone marrow failure syndromes in children. | |
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MedLine Citation:
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PMID: 19203719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone marrow failure (BMF) syndromes include a broad group of diseases of varying etiologies, in which hematopoeisis is abnormal or completely arrested in one or more cell lines. BMF can be an acquired aplastic anemia (AA) or can be congenital, as part of such syndromes as Fanconi anemia (FA), Diamond Blackfan anemia, and Schwachman Diamond syndrome (SDS). In this review, we first address the evolution and current status of bone marrow transplantation (BMT) in the pediatric population in the most common form of BMF, acquired AA. We then discuss pediatric BMT in some of the more common inherited BMF syndromes, with emphasis on FA, in which experience is greatest. It is important to consider the possibility of a congenital etiology in every child (and adult) with marrow failure, because identification of an associated syndrome provides insight into the likely natural history of the disease, as well as prognosis, treatment options for the patient and family, and long-term sequelae both of the disease itself and its treatment. |
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Authors:
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Kasiani C Myers; Stella M Davies |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Volume: 15 ISSN: 1523-6536 ISO Abbreviation: Biol. Blood Marrow Transplant. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-10 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9600628 Medline TA: Biol Blood Marrow Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 279-92 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bone Marrow Diseases / pathology, surgery* Child Child, Preschool Hematopoietic Stem Cell Transplantation / methods* Humans Infant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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