Document Detail

Hematopoietic prostaglandin D synthase.
MedLine Citation:
PMID:  12895599     Owner:  NLM     Status:  MEDLINE    
The biological actions of prostaglandin (PG) D(2) include vasodilatation, bronchoconstriction, inhibition of platelet aggregation, and recruitment of inflammatory cells. Characterization of DP receptor null mice in which antigen-induced airway and inflammatory responses are attenuated and identification of CRTH2 as a novel PGD(2) receptor have shed light on the role of PGD(2) in the immune and inflammatory responses. Hematopoietic PGD synthase (H-PGDS) is a cytosolic enzyme that isomerizes PGH(2), a common precursor for all PGs and thromboxanes, to PGD(2) in a glutathione-dependent manner. H-PGDS is expressed in mast cells, antigen-presenting cells, and Th2 cells, and is the only mammalian member of the Sigma class of cytosolic glutathione S-transferases. In this review, we focus on the molecular biology of H-PGDS, the determination of its three-dimensional structure, characterization of the regulation of its gene expression, and information gleaned from transgenic animals.
Yoshihide Kanaoka; Yoshihiro Urade
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  69     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2003 Aug-Sep
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Smith Building, Room 626C One Jimmy Fund Way, Boston, MA 02115, USA.
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MeSH Terms
Animals, Genetically Modified
Cloning, Molecular
Gene Expression
Glutathione / metabolism
Glutathione Transferase / metabolism
Hematopoietic System / enzymology,  metabolism*
Intramolecular Oxidoreductases / biosynthesis,  genetics,  metabolism*
Mast Cells / metabolism
Piperidines / chemistry,  pharmacology
Prostaglandin D2 / metabolism
Th2 Cells / metabolism
Thromboxane A2 / metabolism
Reg. No./Substance:
0/4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine; 0/Lipocalins; 0/Piperidines; 41598-07-6/Prostaglandin D2; 57576-52-0/Thromboxane A2; 70-18-8/Glutathione; EC Transferase; EC 5.3.-/Intramolecular Oxidoreductases; EC R2 D-isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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