Document Detail


Hematopoietic prostaglandin D synthase.
MedLine Citation:
PMID:  12895599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological actions of prostaglandin (PG) D(2) include vasodilatation, bronchoconstriction, inhibition of platelet aggregation, and recruitment of inflammatory cells. Characterization of DP receptor null mice in which antigen-induced airway and inflammatory responses are attenuated and identification of CRTH2 as a novel PGD(2) receptor have shed light on the role of PGD(2) in the immune and inflammatory responses. Hematopoietic PGD synthase (H-PGDS) is a cytosolic enzyme that isomerizes PGH(2), a common precursor for all PGs and thromboxanes, to PGD(2) in a glutathione-dependent manner. H-PGDS is expressed in mast cells, antigen-presenting cells, and Th2 cells, and is the only mammalian member of the Sigma class of cytosolic glutathione S-transferases. In this review, we focus on the molecular biology of H-PGDS, the determination of its three-dimensional structure, characterization of the regulation of its gene expression, and information gleaned from transgenic animals.
Authors:
Yoshihide Kanaoka; Yoshihiro Urade
Related Documents :
21898539 - Regulation of anti-apoptotic bcl2-proteins by non-canonical interactions: the next step...
21707489 - S1p regulation of macrophage functions in the context of cancer.
22052879 - Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injur...
9831329 - Cyclooxygenase-2 as a therapeutic target.
16094269 - Effect of mechanical compression on the lumbar nerve root: localization and changes of ...
19534809 - Deoxycholate induces cox-2 expression via erk1/2-, p38-mapk and ap-1-dependent mechanis...
8129849 - Characterization of an immunoregulatory cell subset involved in the up-regulation of th...
23549679 - Cytokines as biomarkers of nanoparticle immunotoxicity.
20181789 - Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipoc...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  69     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2003 Aug-Sep
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Smith Building, Room 626C One Jimmy Fund Way, Boston, MA 02115, USA. ykanaoka@rics.bwh.harvard.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Cloning, Molecular
Gene Expression
Glutathione / metabolism
Glutathione Transferase / metabolism
Hematopoietic System / enzymology,  metabolism*
Humans
Intramolecular Oxidoreductases / biosynthesis,  genetics,  metabolism*
Lipocalins
Mast Cells / metabolism
Piperidines / chemistry,  pharmacology
Prostaglandin D2 / metabolism
Th2 Cells / metabolism
Thromboxane A2 / metabolism
Chemical
Reg. No./Substance:
0/4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine; 0/Lipocalins; 0/Piperidines; 41598-07-6/Prostaglandin D2; 57576-52-0/Thromboxane A2; 70-18-8/Glutathione; EC 2.5.1.18/Glutathione Transferase; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.2/prostaglandin R2 D-isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cyclooxygenase enzymes in allergic inflammation and asthma.
Next Document:  The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes.