Document Detail


Hematopoietic cells from bone marrow have the potential to differentiate into cardiomyocytes in vitro.
MedLine Citation:
PMID:  12923898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have indicated that hematopoietic progenitor cells (HPCs) have the capacity to form cardiomyocytes. In the present study, we further examined the cardiac competence of HPCs by asking whether these cells by themselves can be provoked to undergo cardiac differentiation. Our data indicate that in response to growth factor treatment, HPCs from avian bone marrow (BM) can undergo cardiac differentiation, as indicated by their expression of multiple cardiac transcription factors and sarcomeric proteins. Furthermore, coculture experiments with adult mouse BM cells and embryonic heart tissue confirmed that HPCs are able to both integrate into cardiac tissue and differentiate into cardiomyocytes. In an additional set of experiments, we investigated whether other hematopoietic populations might possess cardiac potential by examining whether blood cells that normally are recruited to damaged tissue might act as a source of newly generated cardiomyocytes. Remarkably, macrophages cocultured with cardiac explants also demonstrated an ability to integrate into contractile heart tissue and undergo cardiac differentiation. Thus, our data suggest that the capacity of blood cells to transdifferentiate into cardiomyocytes is not limited to classically defined hematopoietic progenitors.
Authors:
Leonard M Eisenberg; Lindsey Burns; Carol A Eisenberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology     Volume:  274     ISSN:  1552-4884     ISO Abbreviation:  -     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-18     Completed Date:  2004-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101234285     Medline TA:  Anat Rec A Discov Mol Cell Evol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  870-82     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Affiliation:
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. eisenbec@MUSC.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells / cytology*
Cell Differentiation
Cells, Cultured
Chick Embryo
Coculture Techniques
Hematopoietic Stem Cells / cytology*
Macrophages / cytology
Mice
Mice, Inbred ICR
Myocytes, Cardiac / cytology*
Grant Support
ID/Acronym/Agency:
R21-HL-66055/HL/NHLBI NIH HHS

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