| Hematopoietic stem cell transplantation for the treatment of autoimmunity in type 1 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20955158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Type 1 diabetes (T1D) is an autoimmune disease that leads to the destruction of the insulin-producing pancreatic b cells. While there is no current cure, recent work in the field of allogeneic hematopoietic stem cell transplantation (HSCT) and the induction of mixed chimerism, a state in which multilineage hematopoietic populations of both recipient and donor co-exist, has demonstrated that it is possible to provide protection from disease onset, as well as reverse the autoimmune state in spontaneously diabetic mice. Furthermore, the establishment of mixed chimerism induces donor-specific tolerance, providing the potential to normalize glucose regulation via pancreatic islet transplantation without the requirement of life-long immunosuppression. Current studies are aimed at understanding the mechanisms involved in both the reversal of autoimmunity and the induction of tolerance, with the aim of moving this promising approach to curing T1D into the clinic. |
| | |
Authors:
|
Samuel A LoCascio; Joia Spinelli; Josef Kurtz |
Related Documents
:
|
11900278 - The non-immune rip-kb mouse is a useful host for islet transplantation, as the diabetes... 15591438 - Antigen-specific foxp3-transduced t-cells can control established type 1 diabetes. 17303808 - Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in nod mice. 11943868 - Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosin... 171948 - Atypical adrenal insufficiency with failure of the pituitary feedback receptor. a case ... 9706068 - Response to ten generations of divergent selection for tibial dyschondroplasia in broil... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current stem cell research & therapy Volume: 6 ISSN: 1574-888X ISO Abbreviation: Curr Stem Cell Res Ther Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-11 Completed Date: 2011-05-20 Revised Date: 2012-01-19 |
Medline Journal Info:
|
Nlm Unique ID: 101272517 Medline TA: Curr Stem Cell Res Ther Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
|
Emmanuel College, Boston, Massachusetts 02115, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autoantigens / immunology Autoimmunity* Diabetes Mellitus, Experimental / surgery Diabetes Mellitus, Type 1 / immunology, pathology, therapy* Hematopoietic Stem Cell Transplantation* Humans T-Lymphocytes / immunology Transplantation Conditioning Transplantation Immunology Transplantation, Autologous Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
|
0/Autoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gene therapy for immunologic tolerance: using bone marrow-derived cells to treat autoimmunity and he...
Next Document: Autologous hematopoietic stem cell transplantation for systemic sclerosis.