Document Detail


Hematopoiesis and hematopoietic organs in arthropods.
MedLine Citation:
PMID:  23319182     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemocytes (blood cells) are motile cells that move throughout the extracellular space and that exist in all clades of the animal kingdom. Hemocytes play an important role in shaping the extracellular environment and in the immune response. Developmentally, hemocytes are closely related to the epithelial cells lining the vascular system (endothelia) and the body cavity (mesothelia). In vertebrates and insects, common progenitors, called hemangioblasts, give rise to the endothelia and blood cells. In the adult animal, many differentiated hemocytes seem to retain the ability to proliferate; however, in most cases investigated closely, the bulk of hemocyte proliferation takes place in specialized hematopoietic organs. Hematopoietic organs provide an environment where undifferentiated blood stem cells are able to self-renew, and at the same time generate offspring that differentiate into different blood cell types. Hematopoiesis in vertebrates, taking place in the bone marrow, has been subject to intensive research by immunologists and stem cell biologists. Much less is known about blood cell formation in invertebrate animals. In this review, we will survey structural and functional properties of invertebrate hematopoietic organs, with a main focus on insects and other arthropod taxa. We will then discuss similarities, at the molecular and structural level, that are apparent when comparing the development of blood cells in hematopoietic organs of vertebrates and arthropods. Our comparative review is intended to elucidate aspects of the biology of blood stem cells that are more easily missed when focusing on one or a few model species.
Authors:
Melina Grigorian; Volker Hartenstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-15
Journal Detail:
Title:  Development genes and evolution     Volume:  223     ISSN:  1432-041X     ISO Abbreviation:  Dev. Genes Evol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-04-26     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  9613264     Medline TA:  Dev Genes Evol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  103-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthropods / anatomy & histology,  cytology,  physiology*
Cell Lineage
Hematopoiesis*
Hemocytes
Signal Transduction
Stem Cells / cytology,  physiology
Vertebrates / physiology
Grant Support
ID/Acronym/Agency:
GM007185/GM/NIGMS NIH HHS; R01 GM087373/GM/NIGMS NIH HHS
Comments/Corrections

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