Document Detail

Hematological values of 163 normal fetuses between 18 and 30 weeks of gestation.
MedLine Citation:
PMID:  3703624     Owner:  NLM     Status:  MEDLINE    
Utilizing an easy and safe procedure for fetal blood sampling in utero we have studied 409 fetuses for prenatal diagnosis of rubella, toxoplasmosis, hemophilia, and hemoglobinopathies. Retrospectively we selected 163 fetuses confirmed as normal at birth and tested between 18 and 30 wk of gestation to establish normal hematological parameters and to follow the evolution of erythropoiesis, differential counts, hemoglobin synthesis, and hemostasis. Total white blood cell and platelet counts did not change during this period. The lymphocytes represented the main population and we observed a decrease of normoblasts during gestation. The results show a progressive increase of red blood cells and hemoglobin. This evolution is demonstrated by the ratio hemoglobin A to acetylated hemoglobin F. No significant modification of hemostasis was observed over a 12-wk intrauterine gestation. These results provide useful reference values for future investigations.
F Forestier; F Daffos; F Galactéros; J Bardakjian; M Rainaut; Y Beuzard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation Factors / analysis
Erythrocyte Count
Erythrocyte Indices
Fetal Blood / analysis,  cytology*
Gestational Age
Hemoglobins / analysis
Hemoglobins, Abnormal / analysis
Infant, Newborn
Leukocyte Count
Platelet Count
Reference Values
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Hemoglobins; 0/Hemoglobins, Abnormal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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