Document Detail

Hematological profile of twenty-nine tribal compound cases of hemoglobinopathies and G-6-PD deficiency in rural Orissa.
MedLine Citation:
PMID:  18923215     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hematogenetic disorders are commonly encountered in Orissa state in Central-Eastern India. Hemoglobinopathies and G-6-PD deficiency are the most frequently occurring hereditary hemolytic disorders causing high morbidity and mortality in vulnerable people. AIMS: There is no study available reporting combined condition of hemoglobinopathies and G-6-PD deficiency in a single individual from India. This study aims to assess the coincidence of G-6-PD enzyme deficiency with different hemoglobinopathies and beta-thalassemia and to evaluate the influence of combined conditions on the hematological expression. SETTINGS AND DESIGN: The study was carried out in rural Orissa with a random sampling procedure. MATERIALS AND METHODS: Following the standard methodology and techniques, this study highlights 29 tribal cases of compound occurrence of hemoglobinopathy with G-6-PD deficiency in a randomly conducted study in Sundargarh district of Orissa. STATISTICAL ANALYSIS: Results were subjected to statistical analysis. RESULTS: Both female heterozygotes and homozygotes of G-6-PD deficiency in association with different hemoglobinopathies showed reduced values of hematological indices: hemoglobin level, MCV, MCH, MCHC and RBC in comparison to normals. Red cell indices were found further reduced in male G-6-PD deficiency concurrence with hemoglobinopathies in homozygous condition, i.e. sickle cell disease (HbSS) or hemoglobin E disease (HbEE). Hematological indices were significantly lower except WBC counts and fetal hemoglobin in male G-6-PD deficiency with co-existing homozygous sickle cell disease in comparison with counterpart sickle cell trait and normal controls. CONCLUSIONS: Hemoglobin polymorphism with G-6-PD deficiency is advantageous to the community against lethal effects of malaria especially against Plasmodium falciparum at population level, but their combination is harmful at the individual level because of low levels of red cell indices to cope with the routine human physiology.
R S Balgir
Related Documents :
11908635 - Anti-invasive activity of bovine lactoferrin towards group a streptococci.
18635845 - Management of stroke in infants and children: a scientific statement from a special wri...
18322255 - Modulation of erythroid adhesion receptor expression by hydroxyurea in children with si...
14510625 - The role of colony-stimulating factors and granulocyte transfusion in treatment options...
24477735 - Prevalence of juvenile idiopathic arthritis in children aged 6 to 12 years in embu das ...
6216715 - Circulating immune complexes and complement in the course of multiple sclerosis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  62     ISSN:  0019-5359     ISO Abbreviation:  Indian J Med Sci     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2009-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  362-71     Citation Subset:  IM    
Division of Human Genetics, Regional Medical Research Centre ((ICMR), Chandrasekharpur, Bhubaneswar, Orissa, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Erythrocyte Indices
Glycogen Storage Disease Type I / blood,  complications*,  ethnology
Hemoglobinopathies / blood,  complications*,  ethnology
Hemoglobins / analysis
India / epidemiology
Middle Aged
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevalence of hypothyroidism in recurrent pregnancy loss in first trimester.
Next Document:  Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry.