Document Detail


Hematological presentation in systemic lupus erythematosus and its relationship with disease activity.
MedLine Citation:
PMID:  17558704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abnormalities of hematological system are very common in systemic lupus erythematosus (SLE). The aim of the study is to evaluate hematological findings in patients with SLE at the time of referral and their relationship with disease activity and organ involvement. The study was carried consecutive 115 patients, including 20 males and 85 females. Most of the cases had anemia at the time of presentation due to various etiologies. Anemia of chronic disease was seen in 46% and it was the most common encountered picture. The rate of hemolytic anemia was 28%, and Coombs' positivity rate was 22% among our patients. Leukopenia ( < 4.0 x 10(9)/l), neutropenia ( < 1.8 x 10(9)/l), and lymphopenia ( < 1.5 x 10(9)/l) rates were 57, 20, and 82%, respectively. Thrombocytopenia was seen in 40% for < 150 x 10(9)/l, 26% for < 100 x 10(9)/l, and 8% for < 50 x 10(9)/l. Of our patients, 10% had antiphospholipid syndrome (APS) at the time of diagnosis. Increased fibrinogen levels were observed in 35% without relating to disease activity. The rates of C3 and C4 hypocomplementemia were 86 and 64%, respectively, and both are closely correlated with the disease activity. Moreover, C3 hypocomplementemia was more prominent in cases with renal or serosal involvement. Leukopenia and hyperfibrinogenemia were more common in patients with skin/mucosal involvements. C3 hypocomplementemia, APS and elevated IgG levels were more common in our patients with renal involvement. SLE should be kept in mind while evaluating patients with mentioned hematological findings, especially in those with accompanying organ involvements.
Authors:
Eśin Beyan; Cengiz Beyan; Mustafa Turan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hematology (Amsterdam, Netherlands)     Volume:  12     ISSN:  1607-8454     ISO Abbreviation:  Hematology     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708388     Medline TA:  Hematology     Country:  England    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / etiology
Antiphospholipid Syndrome
Complement C3 / analysis
Complement C4 / analysis
Female
Fibrinogen / analysis
Humans
Lupus Erythematosus, Systemic / blood*,  complications,  diagnosis*
Male
Middle Aged
Pancytopenia
Thrombocytopenia
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 9001-32-5/Fibrinogen

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