Document Detail

Hematological parameters in preterm infants from birth to 16 weeks of age with reference to iron balance.
MedLine Citation:
PMID:  18605935     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objective of this study was to describe the natural kinetics of serum soluble transferrin receptor (S-TfR), ferritin and reticulocyte indices in preterm neonates, and to find out whether these analytes relate to hematocrit (Hct) level in determining the need for red cell (RBC) transfusions. METHODS: During a 2-year period, 100 preterm neonates were recruited in a tertiary level neonatal intensive care unit. Inclusion criteria were gestational age < or =34 weeks or birth weight <2000 g. Biochemical markers of iron deficiency and hematological indices were serially analyzed from birth. This report focuses on the first 16 weeks after birth. RESULTS: The trends of the studied analytes were presented with reference ranges. RBC transfusions did not have a significant effect on reticulocyte hemoglobin content (CHr) or reticulocyte count. Reticulocytes were lowest after the first week and S-TfR at 9 weeks of age. CHr and fraction of immature reticulocytes were highest at birth and decreased thereafter. CHr and reticulocyte count were significantly different in two groups determined by Hct level (Hct < or > or =0.30). This difference was not observed in S-TfR or ferritin concentrations. CONCLUSIONS: In addition to reflecting the activity of erythropoiesis, S-TfR seems to reflect iron balance in preterm neonates. By using CHr and reticulocyte, it is possible to obtain more information about iron balance in relation to erythropoiesis, and it might be useful to combine this information with Hct before making a decision about a transfusion.
Enni Mäkelä; Timo I Takala; Pauli Suominen; Jaakko Matomäki; Toivo T Salmi; Allan Rajamäki; Helena Lapinleimu; Liisa Lehtonen; Kerttu Irjala; Päivi M Lähteenmäki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  46     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  551-7     Citation Subset:  IM    
Department of Pediatrics, Turku University Hospital, Turku, Finland.
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MeSH Terms
Blood Chemical Analysis / methods*
Blood Transfusion
Ferritins / blood*
Infant, Newborn
Iron / blood*
Prospective Studies
Receptors, Transferrin / blood*
Reticulocytes / cytology*
Reg. No./Substance:
0/Receptors, Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

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