Document Detail

Hematological parameters and cobalamin status in infants born to smoking mothers.
MedLine Citation:
PMID:  14739552     Owner:  NLM     Status:  MEDLINE    
Hematological parameters, serum cobalamin and folate levels, and the concentrations of the functional markers plasma methylmalonic acid and total homocysteine were determined in 173 newborns and 46 infants at 6 weeks to see whether maternal smoking influences the hematological parameters and the vitamin status of the newborn. At birth, there was a strong inverse correlation between the number of cigarettes smoked per day during pregnancy and red blood cell count (r = -0.56, p = 0.001) and hemoglobin level (r = -0.52, p = 0.003) in the newborns. Neonates born to smoking mothers had lower red blood cell counts and lower hemoglobin and serum cobalamin levels as compared with infants born to nonsmoking mothers. At 6 weeks, maternal smoking significantly predicted the methylmalonic acid and total homocysteine levels, suggesting an influence from smoking on the cobalamin function in these infants.
Anne-Lise Bjørke Monsen; Stein Emil Vollset; Helga Refsum; Trond Markestad; Per Magne Ueland
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-21
Journal Detail:
Title:  Biology of the neonate     Volume:  85     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-22     Completed Date:  2004-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Pediatrics, University of Bergen, Bergen, Norway.
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MeSH Terms
Birth Weight
Erythrocyte Count*
Folic Acid / blood
Gestational Age
Hemoglobins / analysis*
Homocysteine / blood
Infant, Newborn
Logistic Models
Maternal-Fetal Exchange*
Methylmalonic Acid / blood
Smoking / adverse effects*
Vitamin B 12 / blood*
Reg. No./Substance:
0/Hemoglobins; 454-28-4/Homocysteine; 516-05-2/Methylmalonic Acid; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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