Document Detail

Hematological malignancy associated with polymyositis and dermatomyositis.
MedLine Citation:
PMID:  22079677     Owner:  NLM     Status:  Publisher    
The aims of this present study were to: 1) assess the characteristics of hematological malignancies in polymyositis/polymyositis (PM/DM) patients; and 2) determine predictive variables of hematological malignancies in PM/DM patients. We retrospectively reviewed the medical records of 32 patients (14 PM, 18 DM) associated with hematological malignancies. In our 32 PM/DM patients, hematological malignancy was concurrently identified (18.8%) or occurred during the course of PM/DM (31.2%); although, PM/DM more often preceded hematological malignancy onset (50%). We observed that the types of hematological malignancies varied, consisting of: B-cell lymphoma (n=20), T-cell lymphoma (n=4), Hodgkin's disease (n=2), multiple myeloma (n=1), myelodysplastic syndrome without excess of blasts (n=3), hairy cell (n=1) and acute lymphocytic leukemia (n=1). In 21 patients of our 32 patients with PM/DM-associated hematological malignancy (65.6% of cases), PM/DM paralleled the course of hematological malignancy. Finally, we observed that patients with PM/DM-associated hematological malignancies had a poor prognosis, the survival status ranging from 96.9%, 78.1% and 51.4% at 1, 3 and 5years, respectively. Interestingly, we found that patients with hematological malignancies, compared with those without were older and more frequently had DM; on the other hand, these patients less commonly exhibited: joint involvement (p=0.017), interstitial lung disease (p=0.06) and anti-Jo1 antibody (p=0.001). Taken together, our study underscores that the association between PM/DM and hematological malignancy, especially lymphoma, should not be ignored. Our findings also suggest that antisynthetase syndrome may be a protective factor of hematological malignancy in PM/DM patients.
I Marie; L Guillevin; J-F Menard; P Y Hatron; P Cherin; Z Amoura; P Cacoub; H Bachelez; A Buzyn; G Le Roux; J M Ziza; P Brice; J N Munck; F Sarrot-Reynauld; J C Piette; C Larroche
Related Documents :
22371797 - The cardio-renal-anaemia syndrome predicts survival in peritoneally dialyzed patients.
20399007 - Serum lipoprotein levels in patients with neuromyelitis optica elevated but had little ...
21729237 - Hypercoagulability in cirrhosis: causes and consequences.
22491817 - Diagnostic role of procalcitonin in patients with suspected appendicitis.
3950037 - Membranous glomerulonephritis.
6784627 - Total absence of eosinophils in a patient with an allergic disorder.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-30
Journal Detail:
Title:  Autoimmunity reviews     Volume:  -     ISSN:  1873-0183     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Department of Internal medicine, CHU Rouen, Rouen, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Parental support and condom use among transgender female youth.
Next Document:  Predictors of resolution of complex atypical hyperplasia or grade 1 endometrial adenocarcinoma in pr...