Document Detail

Hematological malignancies in chronic inflammatory bowel diseases: report of five cases and review of the literature.
MedLine Citation:
PMID:  17028896     Owner:  NLM     Status:  MEDLINE    
Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate, with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness, and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD (three with ulcerative colitis and two with Crohn's disease) attending our Gastroenterology Unit.
Pietro Crispino; Roberta Pica; Erika Angelucci; Adriana Consolazio; Margherita Rivera; Claudio Cassieri; Paolo Paoluzi
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2006-10-07
Journal Detail:
Title:  International journal of colorectal disease     Volume:  22     ISSN:  0179-1958     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-20     Completed Date:  2007-10-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  553-8     Citation Subset:  IM    
Gastroenterology Unit, Department of Clinical Sciences, University La Sapienza, Policlinico Umberto I, Viale del Policlinico 157, Rome 00161, Italy.
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MeSH Terms
Inflammatory Bowel Diseases / complications*
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Leukemia, Myeloid, Acute / complications*
Lymphoma, B-Cell / complications*
Middle Aged

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