| Hematological malignancies are associated with a lower interferon-a blocking activity than solid tumors. | |
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MedLine Citation:
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PMID: 18426079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interferon (IFN) and especially IFN-alpha exhibit clinical anti-tumor activity against various types of malignant diseases. Natural inhibitors to various cytokines and IFNs have been documented in vitro as well as in vivo. IFN inhibitors have been implicated for the ineffectiveness of IFN treatment in malignant neoplasias. The aim of this study was to investigate the incidence of the IFN inhibiting activity in serum from patients with haematological malignancies versus patients with solid tumours, as an effort to explain, just in part, the different response of these patients to IFN treatment. PATIENTS AND METHODS: Ninety patients with a clinically evident solid tumour and forty-six patients with haematological malignancies were included in the study. Serum samples from all patients were collected before any treatment and stored at -70 degrees until use. Controls sera were selected from 50 apparently healthy blood donors. Interferon-inhibiting activity as well as endogenous IFN-like activity were determined in all serum samples in a cell line highly sensitive to IFN. RESULTS: There was no endogenous IFN-like activity in any of the patients' group or controls' group. Sera from patients with haematological malignancies exhibited IFN-blocking activity at a lower percentage (21.7%) in comparison to sera from patients with solid tumours (56.6%, P<0.001), but at a significantly higher percentage in comparison to sera from controls (P<0.01). CONCLUSIONS: The fact that IFN inhibitors were detected at a significantly lower percentage in sera from patients with haematological malignancies versus patients with solid tumours, could explain in part the better response of the haematological malignancies to IFN treatment. |
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Authors:
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K Karmaniolas; M Dalamaga; S Liatis; A Kaskara; A Rigopoulos; I N Migdalis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research communications in molecular pathology and pharmacology Volume: 117-118 ISSN: 1078-0297 ISO Abbreviation: Res. Commun. Mol. Pathol. Pharmacol. Publication Date: 2005 |
Date Detail:
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Created Date: 2008-04-22 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9437512 Medline TA: Res Commun Mol Pathol Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 65-75 Citation Subset: IM |
Affiliation:
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1st Department of Internal Medicine, NIMTS Hospital, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antineoplastic Agents / antagonists & inhibitors*, blood* Cell Line, Tumor Cytopathogenic Effect, Viral / drug effects Female Hematologic Neoplasms / blood* Humans Interferon Type I, Recombinant / antagonists & inhibitors*, blood* Interferon-alpha / antagonists & inhibitors, blood Male Middle Aged Neoplasms / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Interferon Type I, Recombinant; 0/Interferon-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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