| Hematological and lipid profile changes in sea-level natives after exposure to 3550-m altitude for 8 months. | |
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MedLine Citation:
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PMID: 18081504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this epidemiological study was to determinate the effects on hematological and lipid profile in a young group of newcomers to altitude after being exposed chronically for 8 months to 3550 m (n = 50), age 17.8 +/- 0.7; and not overweight, BMI 22.9 +/- 0.5). Readings taken at altitude on day 1 and on month 8 were hematocrit (Hct, %), hemoglobin (Hb, g/dL), Sa(O(2)), total leukocyte and subset count (mm(3), %), and lipid profile (mg/dL). The same measurements were taken in a comparative group (CG) at sea level (SL). At altitude, elevations of Hct (44.6 +/- 0.4; 51.2 +/- 0.4) and Hb (15.5 +/- 0.1; 17.3 +/- 0.1) were seen (p < 0.001) and none with Hb >/= 21 g/dL. No correlation was observed between Hb and Sa(O(2)), r = 0.11, p > 0.05. Total leukocyte count showed no changes (6037 +/- 74; 6002 +/- 43), but a relative neutropenia (55.2 + -1.5; 50.6 + -1.3) and lymphocytosis (34.2 + 1; 42.4 + 1, p < 0.001) between periods were found and also when compared to SL. Also, an inverse relationship between Sa(O(2)) and total leukocytes on month 8 (r = 0.46; r(2) = 0.204), suggesting a probable representation of a hypoxia effect. Total cholesterol (153.8 +/- 4.5; 157.3 +/- 5.1; p, ns) showed no changes, but a mild decrease of LDL-cholesterol (88.4 +/- 3.3; 81.0 +/- 3.9; p < 0.05), and a rise in triglycerides (121.6 +/- 10.9; 178.8 +/- 11.7; p < 0.001) was found. Changes observed in leukocytes subset count and triglycerides could suggest a contributory role of hypoxic conditions, raising some future epidemiological concerns regarding immune system and fatty acid behaviour at altitude. |
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Authors:
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Patricia Siqués; Julio Brito; Fabiola León-Velarde; Luis Barrios; Juan José De La Cruz; Vasthi López; Rafael Herruzo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: High altitude medicine & biology Volume: 8 ISSN: 1527-0297 ISO Abbreviation: High Alt. Med. Biol. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-17 Completed Date: 2008-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901183 Medline TA: High Alt Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 286-95 Citation Subset: IM; S |
Affiliation:
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Instituto de Estudios de Salud, Universidad Arturo Prat, Chile. psiques@tie.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization
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physiology* Adolescent Adult Altitude* Analysis of Variance Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / blood Female Hematocrit Hemoglobins / physiology* Humans Leukocytes / physiology* Male Reference Values Statistics, Nonparametric Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hemoglobins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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