| Hematological and hemostaseological alterations after warm and cold limb ischemia-reperfusion in a canine model. | |
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MedLine Citation:
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PMID: 19851685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Acute ischemia-reperfusion (I/R) of extremities means serious challenge in the clinical practice. Furthermore, the issue of preventive cooling is still controversial. In this canine model we investigated whether limb I/R -with or without cooling- has an influence on hematological and hemostaseological factors. METHODS: Femoral vessels were exposed and clamped for 3 hours. After release the clamps, 4-hour reperfusion was secured. The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. Before operations, from the excluded limb by the end of ischemia, during the reperfusion, and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters. RESULTS: After I/R activated partial thromboplastin time was elongated on 2nd-4th postoperative days. The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. The hematological parameters and fibrinogen level showed non-specific changes. In excluded ischemic limb the blood composition showed controversial data. Cold ischemia induced larger alterations, however platelet count, hematocrit changed more expressly in warm ischemia. CONCLUSION: These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R. |
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Authors:
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Miklos Szokoly; Norbert Nemeth; Istvan Furka; Iren Miko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 24 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
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Languages: eng Pagination: 338-46 Citation Subset: IM |
Affiliation:
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National Institute of Traumatology, Budapest. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Disorders / blood*, etiology Body Temperature Cold Temperature / adverse effects* Disease Models, Animal Dogs Fibrinogen / analysis Hemorheology Hemostasis Hindlimb / blood supply* Ischemia / blood* Lower Extremity / blood supply* Random Allocation Reperfusion Injury / blood*, complications |
| Chemical | |
Reg. No./Substance:
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9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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