| Hematological abnormalities of acute exposure to hexachloroethane smoke inhalation. | |
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MedLine Citation:
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PMID: 20384461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There has been no human epidemiological data regarding potential hematological effects of hexachloroethane-zinc oxide (HC/ZnO) inhalation. This is the first epidemiological study to investigate whether HC/ZnO inhalation exposure can induce hematological abnormalities in exposed soldiers. Twenty soldiers, who were exposed to a high concentration of HC/ZnO smoke for 3-10 min in a narrow tunnel (0.6 m in width) during military training, were recruited as the exposed group (n = 20). Another 64 soldiers, who were not visiting the explosion areas, were recruited as controls. Venous blood was collected from all participants for analyses of hematological parameters. After adjustment for potential confounders, there were significant differences in weekly mean hemoglobin (HB), red blood cell count (RBC), and hematocrit (HCT) between exposed soldiers and controls (p < .01) at the first follow-up through the first 4 weeks following exposure. In addition, mean white blood cell count (WBC) of exposed soldiers was significantly higher than that of controls at the 4-week follow-up. Further analysis showed HB, RBC, and HCT changes during the 1st week after exposure and reach lowest levels during the 2nd week. HB, RBC, HCT, and WBC returned to normal within 11 weeks after the HC/ZnO smoke exposure. All other hematological parameters remained unchanged at 72 weeks after the event. The authors concluded that inhalation of HC/ZnO smoke can induce acute, temporally related hematological abnormalities. |
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Authors:
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Cheng-Hsiu Chou; Tung-Wei Kao; Saou-Hsing Liou; Hong-I Chen; Hsiu-Ying Ku; Hui-Jung Chuang; Ching-Hui Loh |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Inhalation toxicology Volume: 22 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 486-92 Citation Subset: IM |
Affiliation:
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Department of Family Medicine, Hualien Armed Forced General Hospital, Hualien, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Sectional Studies Erythrocyte Count Erythrocytes / cytology, drug effects Ethane / analogs & derivatives*, toxicity Follow-Up Studies Hematocrit Hematologic Diseases / blood, chemically induced* Hemoglobins / analysis Humans Hydrocarbons, Chlorinated / toxicity* Inhalation Exposure / adverse effects* Leukocyte Count Leukocytes / cytology, drug effects Military Personnel Occupational Exposure / adverse effects* Smoke* Zinc Oxide / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Hydrocarbons, Chlorinated; 0/Smoke; 1314-13-2/Zinc Oxide; 67-72-1/hexachloroethane; 74-84-0/Ethane |
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