Document Detail

Hematologic neoplasia associated with primary mediastinal germ-cell tumors.
MedLine Citation:
PMID:  2158625     Owner:  NLM     Status:  MEDLINE    
Between September 1983 and December 1988, we observed 16 cases of hematologic neoplasia associated with mediastinal germ-cell tumors. Twenty-eight similar cases have been reported in the literature. A review of the clinical and cytogenetic details in these patients suggests that the hematologic neoplasia is not the result of cisplatin-based chemotherapy of the mediastinal germ-cell cancer. This syndrome was found only in patients with nonseminomatous mediastinal germ-cell tumors, particularly those with serologic or histologic evidence of yolk-sac elements. The two most common hematologic neoplasms seen in this syndrome were acute megakaryoblastic leukemia and malignant histiocytosis. Consistent cytogenetic abnormalities have not yet been identified, but the finding of the marker chromosome isochromosome (12p) in the mediastinal germ-cell tumor and associated leukemic blasts in one patient suggests that these tumors may arise from a common progenitor cell.
C R Nichols; B J Roth; N Heerema; J Griep; G Tricot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The New England journal of medicine     Volume:  322     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1425-9     Citation Subset:  AIM; IM    
Department of Medicine, Indiana University School of Medicine, Indianapolis 46223.
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MeSH Terms
Bone Marrow Diseases / complications
Chromosomes, Human, Pair 12
Hematologic Diseases / complications*,  genetics
Histiocytic Sarcoma / genetics,  pathology
Leukemia* / genetics,  pathology
Leukemia, Megakaryoblastic, Acute / genetics,  pathology
Mediastinal Neoplasms* / drug therapy,  genetics
Middle Aged
Neoplasms, Germ Cell and Embryonal* / drug therapy,  genetics
Neoplasms, Multiple Primary* / genetics,  pathology
Grant Support
M01-RR00750-06/RR/NCRR NIH HHS

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