Document Detail

Hematologic effects of phenytoin therapy during pregnancy.
MedLine Citation:
PMID:  662246     Owner:  NLM     Status:  MEDLINE    
Serum folate and plasma phenytoin concentrations were measured in 10 epileptic gravidas who did not receive folate supplementation. Mean serum folate concentration averaged 5.0 ng/ml during the second and third trimesters of pregnancy but significantly decreased to 2.9 ng/ml during nonpregnant evaluation 1 to 12 months following delivery. No patient exhibited anemia or macrocytosis suggestive of cellular folate deficiency either during or following pregnancy. Although phenytoin dosage remained relatively constant, plasma phenytoin concentrations during pregnancy were significantly lower than nonpregnant concentrations. The improvement in folate status observed during pregnancy may be related to lowered plasma phenytoin concentrations.
R G Strauss; R E Ramsay; L J Willmore; B J Wilder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  51     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  682-5     Citation Subset:  AIM; IM    
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MeSH Terms
Carotenoids / metabolism
Epilepsy / drug therapy*,  metabolism
Folic Acid / blood*
Folic Acid Deficiency / chemically induced
Hematologic Tests
Phenytoin / administration & dosage,  adverse effects*,  blood,  therapeutic use
Pregnancy Complications / drug therapy*,  metabolism
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Seizures / drug therapy,  metabolism
Xylose / metabolism
Reg. No./Substance:
0/Xylose; 36-88-4/Carotenoids; 57-41-0/Phenytoin; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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