Document Detail


Hematologic effects of linezolid: summary of clinical experience.
MedLine Citation:
PMID:  12121967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Linezolid has been associated with reversible myelosuppression. Clinical trial data were evaluated for anemia, thrombocytopenia, and neutropenia. Thrombocytopenia and a slight increased risk for anemia were evident at > or =2 weeks of linezolid treatment. Hematologic abnormalities were consistent with mild, reversible, duration-dependent myelosuppression. Appropriate monitoring is warranted with linezolid use.
Authors:
Stanton L Gerson; Sheldon L Kaplan; Jon B Bruss; Vu Le; Felix M Arellano; Barry Hafkin; David J Kuter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  46     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2003-01-13     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2723-6     Citation Subset:  IM    
Affiliation:
Division of Hematology/Oncology and Ireland Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4937, USA. slg5@cwru.edu
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MeSH Terms
Descriptor/Qualifier:
Acetamides / adverse effects*
Anemia / blood*,  chemically induced*
Anti-Infective Agents / adverse effects*
Blood Cell Count
Clinical Trials as Topic
Hemoglobins / metabolism
Humans
Neutropenia / blood,  chemically induced
Oxazolidinones / adverse effects*
Retrospective Studies
Thrombocytopenia / blood,  chemically induced
Chemical
Reg. No./Substance:
0/Acetamides; 0/Anti-Infective Agents; 0/Hemoglobins; 0/Oxazolidinones; 165800-03-3/linezolid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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