Document Detail

Hematogenous metastases of carcinoma to dorsal root ganglia.
MedLine Citation:
PMID:  195438     Owner:  NLM     Status:  MEDLINE    
Hematogenous metastases of carcinoma to dorsal root ganglia was found in 2 of approximately 500 consecutive autopsies in which a lumbar dorsal root ganglion was routinely examined microscopically. The primary tumors were poorly differentiated colonic adenocarcinoma and oat cell carcinoma of the lung, both with widespread hematogenous metastases which spared the central nervous system. No symptoms were detected clinically. In the same series of patients the sural nerve as well as the lumbar plexus were histologically sampled but no examples of distant endoneurial metastases were found. The vascular endothelium of dorsal root ganglia is fenestrated and, presumably as a consequence, provides no blood-ganglion barrier. This microvascular difference may account for the susceptibility of the ganglia to metastases when compared to nerve trunks which posses unfenestrated endothelium and blood-nerve barrier.
P C Johnson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  38     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  171-2     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / pathology
Bronchial Neoplasms / pathology
Carcinoma, Small Cell / pathology
Ganglia, Spinal / pathology*
Lumbosacral Plexus / pathology
Lung Neoplasms / pathology
Middle Aged
Neoplasm Metastasis
Peripheral Nervous System Neoplasms / pathology*
Sural Nerve / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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