Document Detail

Hematogenous development of rat mature granulocytic leukemia--comparison of 2,7-FAA-induced and transplanted leukemia.
MedLine Citation:
PMID:  281109     Owner:  NLM     Status:  MEDLINE    
The oral administration of N,'N-2,7-fluorenylenebis-acetamide (2,7-FAA) induces leukemia, especially mature granulocytic leukemia in rats. We compared the degree of infiltration of 2,7-FAA-induced mature granulocytic leukemia with that of transplanted leukemia for the purpose of proving hematogenous development of leukemia. The bone marrow, spleen and liver were examined in the cases of diffuse lesion of 2,7-FAA-induced and transplanted leukemia. The average degree of infiltration of both 2,7-FAA-induced and transplanted leukemia was high in the bone marrow, medium in the spleen, and low in the liver. Intravenous transplantation of malignant neoplasm is an example of hematogenous metastasis. The similarity of infiltration between 2,7-FAA-induced and transplanted leukemia suggests that the former is spread by hematogenous metastasis.
S Takayama; M Fujiwara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  28     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  523-9     Citation Subset:  IM    
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MeSH Terms
2-Acetylaminofluorene / analogs & derivatives*
Leukemia, Experimental / blood,  pathology
Leukemia, Myeloid / blood,  chemically induced,  etiology,  pathology*
Neoplasm Metastasis
Neoplasm Transplantation
Neoplastic Cells, Circulating*
Transplantation, Homologous
Reg. No./Substance:
0/Fluorenes; 53-96-3/2-Acetylaminofluorene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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