Document Detail

Hemashield implantation in young patients with congenital cardiovascular lesions.
MedLine Citation:
PMID:  10892947     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: There is substantial controversy regarding the use of Hemashield in young patients. METHODS: Twenty-one consecutive patients younger than 20 years of age with a variety of congenital cardiovascular lesions underwent surgical procedures using a Hemashield woven graft. Hemashield was used for reconstruction of the aortic wall (n = 16), ventricular septum (n = 10), and right ventricular free wall or pulmonary artery (n = 6). RESULTS: A sterile inflammatory reaction was observed including high fever, increased white cell count, and elevated plasma C-reactive protein concentration for up to 4 weeks after implantation. Multivariable analysis identified the use of Hemashield in the right ventricular free wall or pulmonary artery as an incremental risk factor for elevation of plasma C-reactive protein concentration during the first 3 weeks after implantation (p = 0.002). There were no midterm complications including restenosis of the grafts in the right ventricular outflow tract. CONCLUSIONS: Hemashield can be used in a variety of situations for reconstruction of congenital cardiovascular lesions in young patients. Impregnated collagen can cause a significant systemic inflammatory reaction for several weeks after implantation, especially when used in the low-pressure right heart.
R Aeba; T Katogi; S Kawada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  69     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-25     Completed Date:  2000-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1920-4; discussion 1924-5     Citation Subset:  AIM; IM    
Division of Cardiovascular Surgery, Keio University, Tokyo, Japan.
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MeSH Terms
Blood Vessel Prosthesis Implantation*
Child, Preschool
Heart Defects, Congenital / surgery*
Postoperative Complications / etiology
Prosthesis Design
Risk Factors
Systemic Inflammatory Response Syndrome / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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