Document Detail

Hemangioendothelioma of the thyroid gland--true endothelioma or anaplastic carcinoma?
MedLine Citation:
PMID:  18788166     Owner:  NLM     Status:  MEDLINE    
After a critical histological re-examination of 26 cases of malignant hemangioendothelioma of the thyroid, and a comparison with 51 cases of anaplastic spindle and giant cell carcinoma, it becomes obvious that traumatic and shrinkage artefacts due to fixation, as well as superimposition of neoplastic and repair processes due to regressive changes--almost always seen in malignant hemangioendothelioma associated nodular goiter--may be misinterpreted as neoplastic vascular spaces (and therefore angioblastic tumour differentiation). Focal epithelial arrangements of tumour cells often observed in these malignant hemangioendotheliomas and the lack of objective light microscopic differential diagnostic criteria of anaplastic spindle and giant cell carcinoma make the high incidence of endotheliomas of the thyroid in European endemic goiter regions very questionable. Compared with anaplastic spindle and giant cell carcinoma, the incidence for (1) extrathyroid tumours that infiltrate into the trachea or the oesophagus, (2) lymph node metastases and (3) distant metastases is not statistically different in malignant hemangioendothelioma. Therefore we conclude that the tumours classified as malignant hemangioendothelioma in goitrous areas represent a special growth pattern of anaplastic spindle and giant cell carcinoma within adenomatous glands rather than a distinct tumour type.
K Krisch; J H Holzner; R Kokoschka; R Jakesz; B Niederle; R Roka
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  170     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  230-42     Citation Subset:  IM    
Department of Pathology, University of Vienna Medical School, Vienna, Austria.
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MeSH Terms
Carcinoma / classification,  pathology*
Carcinoma, Giant Cell / classification,  pathology*
Diagnostic Errors*
Hemangioendothelioma / classification,  pathology*
Middle Aged
Specimen Handling
Terminology as Topic
Thyroid Neoplasms / classification,  pathology*

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