Document Detail

Helpfulness of the combination of acetic acid and FICE in the detection of Barrett's epithelium and Barrett's associated neoplasias.
MedLine Citation:
PMID:  22563172     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the mucosal morphology in Barrett's oesophagus by chromo and magnifying endoscopy.
METHODS: A prospective pilot study at a tertiary medical centre was conducted to evaluate the use of acetic acid pulverisation combined with virtual chromoendoscopy using Fujinon intelligent chromoendoscopy (FICE) for semiological characterization of the mucosal morphology in Barrett's oesophagus and its neoplastic complications. Upper endoscopy using high definition white light, 2% acid acetic pulverisation and FICE with high definition videoendoscopy were performed in 20 patients including 18 patients who presented with aspects of Barrett's oesophagus at endoscopy examination. Two patients used as controls had normal endoscopy and histological results. Prospectively, videos were watched blind from histological results by three trained FICE technique endoscopists.
RESULTS: The videos of patients with high-grade dysplasia showed an irregular mucosal pattern in 14% using high definition white light endoscopy and in 100% using acid acetic-FICE combined. Videos did not identify irregular vascular patterns using high definition white light endoscopy, while acid acetic-FICE combined visualised one in 86% of cases.
CONCLUSION: Combined acetic acid and FICE is a promising method for screening high-grade dysplasia and early cancer in Barrett's oesophagus.
Marine Camus; Romain Coriat; Sarah Leblanc; Catherine Brezault; Benoit Terris; Elise Pommaret; Marianne Gaudric; Ariane Chryssostalis; Frederic Prat; Stanislas Chaussade
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-09-17     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1921-5     Citation Subset:  IM    
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MeSH Terms
Acetic Acid / diagnostic use*
Barrett Esophagus / diagnosis*,  pathology
Endoscopy, Gastrointestinal / methods*
Esophageal Neoplasms / diagnosis*,  pathology
Esophagus / pathology
Middle Aged
Pilot Projects
Prospective Studies
Reg. No./Substance:
Q40Q9N063P/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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