Document Detail


Helper T-cell identity and evolution of differential transcriptomes and epigenomes.
MedLine Citation:
PMID:  23405893     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD4(+) T cells are critical for the elimination of an immense array of microbial pathogens. Among the ways they accomplish this task is to generate progeny with specialized, characteristic patterns of gene expression. From this perspective, helper cells can be viewed as pluripotent precursors that adopt distinct cell fates. Although there are aspects of helper cell differentiation that can be modeled as a classic cell fate commitment, CD4(+) T cells also maintain considerable flexibility in their transcriptional program. This makes sense in terms of host defense, but raises the question of how these remarkable cells balance both these requirements, a high degree of specific gene expression and the capacity for plasticity. In this review, we discuss recent advances in our understanding of CD4(+) T-cell specification, focusing on how genomic perspectives have influenced our views of these processes. The relative contributions of sensors of the cytokine milieu, especially the signal transducer and activator of transcription family transcription factors, 'master regulators', and other transcription factors are considered as they relate to the helper cell transcriptome and epigenome.
Authors:
Golnaz Vahedi; Amanda C Poholek; Timothy W Hand; Arian Laurence; Yuka Kanno; John J O'Shea; Kiyoshi Hirahara
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  252     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-18     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-40     Citation Subset:  IM    
Copyright Information:
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
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MeSH Terms
Descriptor/Qualifier:
Biological Evolution
Cell Differentiation
Cell Lineage / genetics,  immunology*
Cytokines / biosynthesis,  immunology
Epigenesis, Genetic / immunology*
Genes, Regulator / immunology*
Humans
Signal Transduction
T-Lymphocytes, Helper-Inducer / cytology,  immunology*
Transcription Factors / genetics,  immunology
Transcription, Genetic
Transcriptome / immunology*
Grant Support
ID/Acronym/Agency:
ZIA AR041159-05/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Transcription Factors
Comments/Corrections

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