| Heliox and noninvasive positive-pressure ventilation: a role for heliox in exacerbations of chronic obstructive pulmonary disease? | |
| | |
MedLine Citation:
|
PMID: 16723041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Evidence-based respiratory therapy for exacerbations of chronic obstructive pulmonary disease (COPD) includes oxygen, inhaled bronchodilators, and noninvasive positive-pressure ventilation. Examining the physics of gas flow, a case can be made either for or against the use of helium-oxygen mixture (heliox) in the care of patients with COPD. The evidence for the use of heliox in patients with COPD exacerbation is not strong at present. Most of the peer-reviewed literature consists of case reports, case series, and physiologic studies in small samples of carefully selected patients. Some patients with COPD exacerbation have a favorable physiologic response to heliox therapy, but predicting who will be a responder is difficult. Moreover, the use of heliox is hampered by the lack of widespread availability of an approved heliox delivery system. Appropriately designed randomized controlled trials with patient-important outcomes, such as avoidance of intubation, decreased intensive-care-unit and hospital days, and decreased cost of therapy, are sorely needed to establish the role of heliox in patients with COPD exacerbation, including those receiving noninvasive positive-pressure ventilation. Lacking such evidence, the use of heliox in patients with COPD exacerbation cannot be considered standard therapy. |
| | |
Authors:
|
Dean R Hess |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Respiratory care Volume: 51 ISSN: 0020-1324 ISO Abbreviation: Respir Care Publication Date: 2006 Jun |
Date Detail:
|
Created Date: 2006-05-25 Completed Date: 2006-08-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7510357 Medline TA: Respir Care Country: United States |
Other Details:
|
Languages: eng Pagination: 640-50 Citation Subset: IM |
Affiliation:
|
Department of Respiratory Care, Massachusetts General Hospital, Boston, MA 02114, USA. dhess@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anoxia
/
physiopathology Biophysical Phenomena Biophysics Carbon Dioxide / metabolism Functional Residual Capacity Helium / administration & dosage, pharmacology, therapeutic use* Humans Oxygen / administration & dosage, pharmacology, therapeutic use* Positive-Pressure Respiration* Pulmonary Disease, Chronic Obstructive / drug therapy*, physiopathology, therapy Respiratory Function Tests Work of Breathing / drug effects |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 58933-55-4/heliox; 7440-59-7/Helium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heliox during mechanical ventilation.
Next Document: Opportunities and risks of using heliox in your clinical practice.