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Heliox non-invasive ventilation for preventing extubation failure in preterm infants.
MedLine Citation:
PMID:  23145834     Owner:  NLM     Status:  Publisher    
Abstract Objectives: Our aim was to assess whether non-invasive ventilation with heliox may decrease the incidence of extubation failure in preterm infants with RDS. Methods: Infants <29 weeks of gestation were treated immediately after extubation with heliox combined with nasal continuous airway pressure (Hx-NCPAP) or bilevel NCPAP (Hx-BiPAP) for 24 hours, while infants in the control groups were treated with conventional NCPAP or BiPAP. The primary endpoint was the comparison of the extubation failure rate in the two groups, where failure was defined as the need for MV during the 24h following extubation. Results: Eighteen infants were assigned to the heliox group and 18 to the control group. The extubation failure rate was similar (p=0.249) in the heliox (n=6; 33%) and in the control group (n=9; 50%), but required mean airway pressure (MAP: 4.0±1.0 vs. 4.8±1.2 cm H(2)O; p=0.037) and PaCO(2) (39±8 vs. 52±7 mmHg; p<0.001) at 24 h of treatment were lower in the heliox group. Conclusions: Non-invasive ventilation with heliox was not effective in decreasing extubation failure in preterm infants with RDS, but did improve their respiratory function. Our findings might support the planning of large randomized controlled studies to evaluate the effectiveness of heliox non-invasive ventilation for decreasing extubation failure in premature infants.
Carlo Dani; Giulia Fontanelli; Ilaria Lori; Federica Favelli; Chiara Poggi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Italy.
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