Document Detail


Heligmosomoides polygyrus and Trypanosoma congolense infections in mice: effect of immunisation by abbreviated larval infection.
MedLine Citation:
PMID:  10447189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concurrent African trypanosome and gastrointestinal helminth infections are prevalent in sub-humid savannah where they are endemic. However, acquired resistance in animals varies with their responder status and exposure. As a guide to study in the definitive hosts, the effects of Trypanosoma congolense infection on the development and maintenance of homologous Heligmosomoides polygyrus resistance were investigated in outbred TO mice. These mice were immunised by abbreviation of larval infection. Immune or naive mice were either infected with 500 infective larvae (L3) of H. polygyrus and/or 10(4) bloodstream forms of T. congolense or were not infected. The outcome of infection was monitored by routine parasitological and immunological techniques for 30 days after the day of the T. congolense infection. Significantly more immune mice concurrently infected with both parasites survived than did immune mice in which H. polygyrus was superimposed on a 10-day-old T. congolense infection. Although all the mice in this latter group died before the end of the experiment, larval immunisation prolonged their survival, relative to similarly treated naive mice. The antibody titres to H. polygyrus in the sera of immune mice challenged with H. polygyrus alone were significantly higher than those of immune mice concurrently infected with both parasites but the levels of protection obtained were comparable. It is concluded that T. congolense may not completely block the strong acquired resistance induced by abbreviated H. polygyrus larval infection in TO mice but is capable of interfering with protective responses, especially if the trypanosome infection occurs prior to H. polygyrus challenge infection.
Authors:
B B Fakae; L J Harrison; C A Ross; M M Sewell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  85     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-05     Completed Date:  1999-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  13-23     Citation Subset:  IM    
Affiliation:
Department of Veterinary Parasitology and Entomology, University of Nigeria, Nsukka.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anthelmintics / therapeutic use
Antibodies, Helminth / blood
Antibodies, Protozoan / blood
Blood / parasitology
Enzyme-Linked Immunosorbent Assay / veterinary
Feces / parasitology
Female
Hematocrit / veterinary
Immunization / methods,  veterinary*
Ivermectin / therapeutic use
Larva / immunology
Mice
Nematospiroides dubius / immunology*
Parasite Egg Count / veterinary
Parasitemia / veterinary
Random Allocation
Ruminants / parasitology*
Specific Pathogen-Free Organisms
Strongylida Infections / complications,  immunology,  veterinary*
Trypanosoma congolense / immunology*
Trypanosomiasis, African / complications,  immunology,  veterinary*
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Antibodies, Helminth; 0/Antibodies, Protozoan; 70288-86-7/Ivermectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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