Document Detail


Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation.
MedLine Citation:
PMID:  22215939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR).
METHODS: Maternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer.
RESULTS: A significantly higher percentage of H. pylori seropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR.
CONCLUSION: Our data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise.
Authors:
Simona Cardaropoli; Alessandro Rolfo; Annalisa Piazzese; Antonio Ponzetto; Tullia Todros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-03-02     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5156-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / blood
Antigens, Bacterial / immunology
Female
Fetal Growth Retardation / blood,  etiology*,  virology
Helicobacter Infections / blood,  complications*,  physiopathology*
Helicobacter pylori / pathogenicity*
Humans
Placenta / metabolism
Pre-Eclampsia / blood,  etiology*,  virology
Pregnancy / blood
Pregnancy Complications, Infectious / blood,  etiology*,  physiopathology*,  virology
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antigens, Bacterial
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